Pseudoginsenoside-F-11 attenuates morphine-induced signalling in Chinese hamster ovary-mu cells
文献类型：期刊论文
| 作者 | Li, Z; Xu, NJ; Wu, CF; Xiong, Y; Fan, HP; Zhang, WB; Sun, Y; Pei, G |
| 刊名 | NEUROREPORT
 |
| 出版日期 | 2001 |
| 卷号 | 12期号:7页码:1453-1456 |
| 关键词 | Chinese hamster ovary (CHO)-mu cells morphine opioid receptor pseudoginsenoside-F-11 |
| 通讯作者 | Wu, CF (reprint author), Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110015, Peoples R China., |
| 英文摘要 | Pseudoginsenoside-F-II (PFII), an ocotillol type saponin isolated from Panax quinquefolium L., has been shown to antagonize the behavioral actions of morphine. Biochemical experiments revealed that PFII could inhibit diprenorphine (DIP) binding with an IC50 of similar to6.1 muM and reduced the binding potency of morphine in Chinese hamster ovary (CHO)-mu cells. Furthermore, PFII significantly attenuated morphine-stimulated [S-35]GTP gammaS binding in a dose dependent manner, and strongly decreased the efficacy of morphine to inhibit intracellular cAMP production. In addition, PFII pretreatment could also significantly inhibit naloxone induced cAMP overshoot in the morphine-pretreated cells. However, PFII per se had no effect on either [S-35]GTP gammaS binding or intracellular cAMP accumulation. These data suggested that PFII antagonized the morphine stimulated opioid receptor signalling directly at the cellular level. NeuroReport 12:1453-1456 (C) 2001 Lippincott Williams & Wilkins. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | DELTA-OPIOID RECEPTOR ; HOMOLOGOUS DESENSITIZATION ; PHARMACOLOGICAL ACTIONS ; VIETNAMESE GINSENG ; PANAX-GINSENG ; MICE ; ACTIVATION ; TOLERANCE ; SAPONINS ; KAPPA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000169077800027 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2695]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Li, Z,Xu, NJ,Wu, CF,et al. Pseudoginsenoside-F-11 attenuates morphine-induced signalling in Chinese hamster ovary-mu cells[J]. NEUROREPORT,2001,12(7):1453-1456. |
| APA | Li, Z.,Xu, NJ.,Wu, CF.,Xiong, Y.,Fan, HP.,...&Pei, G.(2001).Pseudoginsenoside-F-11 attenuates morphine-induced signalling in Chinese hamster ovary-mu cells.NEUROREPORT,12(7),1453-1456. |
| MLA | Li, Z,et al."Pseudoginsenoside-F-11 attenuates morphine-induced signalling in Chinese hamster ovary-mu cells".NEUROREPORT 12.7(2001):1453-1456. |
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