Forced expression of the Oct-4 gene influences differentiation of embryonic stem cells
文献类型：期刊论文
| 作者 | Du, ZW; Cong, XQ; Yao, Z |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2001 |
| 卷号 | 46期号:17页码:1446-1449 |
| 关键词 | Oct-4 gene embryonic stem cell differentiation |
| 通讯作者 | Du, ZW (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China., |
| 英文摘要 | By transfecting an Oct-4 expression plasmid Into embryonic stem cells (ES cells), the ES-O cell line was constructed, which sustained the expression of Oct-4 gene when induced by retinoic acid. Forced expression of Oct-4 gene could not sustain the stem property of ES-O cells without the differentiation inhibiting factor LIF, but if LIF exists, forced expression of Oct-4 gene could enhance the ability to sustain the undifferentiation state and Inhibit cell differentiation induced by retinoic acid. It was Indicated that Oct-4 must cooperate with LIF to sustain the undifferentiation state of ES cells. During the cell differentiation, ES-O cells tend to differentiate Into neural cells, suggesting that forced expression of Oct-4 gene may be In relation with the differentiation of neuroderm. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | TRANSCRIPTION FACTOR ; MAMMALIAN EMBRYO ; GERMLINE ; TOTIPOTENCY ; CARCINOMA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000171508000010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2712]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Du, ZW,Cong, XQ,Yao, Z. Forced expression of the Oct-4 gene influences differentiation of embryonic stem cells[J]. CHINESE SCIENCE BULLETIN,2001,46(17):1446-1449. |
| APA | Du, ZW,Cong, XQ,&Yao, Z.(2001).Forced expression of the Oct-4 gene influences differentiation of embryonic stem cells.CHINESE SCIENCE BULLETIN,46(17),1446-1449. |
| MLA | Du, ZW,et al."Forced expression of the Oct-4 gene influences differentiation of embryonic stem cells".CHINESE SCIENCE BULLETIN 46.17(2001):1446-1449. |
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