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An antimicrobial peptide gene found in the male reproductive system of rats
文献类型：期刊论文
| 作者 | Li, P; Chan, HC; He, B; So, SC; Chung, YW; Shang, Q; Zhang, YD; Zhang, YL |
| 刊名 | SCIENCE
 |
| 出版日期 | 2001 |
| 卷号 | 291期号:5509页码:1783-1785 |
| 通讯作者 | Zhang, YL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | Little is known about the innate defense mechanisms of the male reproductive tract. We cloned a 385-base pair complementary DNA and its genomic DNA named Bin1b that is exclusively expressed in the caput region of the rat epididymis and that is responsible for sperm maturation, storage, and protection. Bin1b exhibits structural characteristics and antimicrobial activity similar to that of cationic antimicrobial peptides, beta -defensins. Bin1b is maximally expressed when the rats are sexually mature and can be up-regulated by inflammation. Bin1b appears to be a natural epididymis-specific antimicrobial peptide that plays a role in reproductive tract host defense and male fertility. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | INNATE HOST-DEFENSE ; CHLAMYDIA-TRACHOMATIS ; ANION SECRETION ; MESSENGER-RNA ; EPIDIDYMIS ; ANTIBIOTICS ; EPITHELIA ; BETA-DEFENSIN-1 ; EXPRESSION ; CHANNEL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000167320600058 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2722]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Li, P,Chan, HC,He, B,et al. An antimicrobial peptide gene found in the male reproductive system of rats[J]. SCIENCE,2001,291(5509):1783-1785. |
| APA | Li, P.,Chan, HC.,He, B.,So, SC.,Chung, YW.,...&Zhang, YL.(2001).An antimicrobial peptide gene found in the male reproductive system of rats.SCIENCE,291(5509),1783-1785. |
| MLA | Li, P,et al."An antimicrobial peptide gene found in the male reproductive system of rats".SCIENCE 291.5509(2001):1783-1785. |
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