Identification of differentially expressed genes in the denervated rat hippocampus by cDNA arrays
文献类型：期刊论文
| 作者 | Ying, GX; Huang, C; Jing, NH; Zhou, CF |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2001 |
| 卷号 | 306期号:1页码:121-125 |
| 关键词 | denervated hippocampus cDNA array differential screening gene expression |
| 通讯作者 | Zhou, CF (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Physiol, Neurobiol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | To elucidate the molecular mechanism underlying the physiological responses to injury in the central nervous system, gene expression profiles in rodent hippocampus following perforant path transection were investigated using cDNA array hybridization. Of the 8000 arrayed clones, 47 exhibited differential expression by >3-fold difference in the denervated hippocampus from control, with 15 up-regulated and 22 down-regulated. They can be functionally assigned into several classes, among which the most prominent are those coding proteins involved in macromolecules synthesis and processing. Northern blot analysis verified the validation of the aforementioned array data. These results throw some new light on the physiological responses of the hippocampus to entorhinal deafferentation at molecular level. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | ENTORHINAL CORTEX LESION ; CL COTRANSPORTER ; UP-REGULATION ; NEURONS ; PLASTICITY ; ASTROCYTES ; CYSTATIN ; MEMBER ; FAMILY ; RNA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000169465800030 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2724]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Ying, GX,Huang, C,Jing, NH,et al. Identification of differentially expressed genes in the denervated rat hippocampus by cDNA arrays[J]. NEUROSCIENCE LETTERS,2001,306(1):121-125. |
| APA | Ying, GX,Huang, C,Jing, NH,&Zhou, CF.(2001).Identification of differentially expressed genes in the denervated rat hippocampus by cDNA arrays.NEUROSCIENCE LETTERS,306(1),121-125. |
| MLA | Ying, GX,et al."Identification of differentially expressed genes in the denervated rat hippocampus by cDNA arrays".NEUROSCIENCE LETTERS 306.1(2001):121-125. |
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