The scaffolding protein CASK mediates the interaction between rabphilin3a and beta-neurexins
文献类型：期刊论文
| 作者 | Zhang, Y; Luan, ZD; Liu, AH; Hu, GX |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2001 |
| 卷号 | 497期号:1页码:99-102 |
| 关键词 | CASK beta-neurexin rabphilin3a synaptic vesicle exocytosis yeast two-hybrid system |
| 通讯作者 | Hu, GX (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Max Planck Guest Lab, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | CASK, a member of the membrane-associated guanylate kinase (MAGUK) superfamily, binds to the carboxyl-terminus of beta -neurexins on the intracellular side of the presynaptic membrane. The guanylate kinase-like (GUK) domains of MAGUKs lack kinase activities, but might he important for mediating specific protein-protein interaction. By a yeast two-hybrid approach, we identified an interaction between the GUK domain of CASK and the C2B domain of rabphilin3a, a presynaptic protein involved in synaptic vesicle exocytosis. The interaction was confirmed by in vitro CST pull-down and co-immunoprecipitation assays. It,vas proposed that presynaptic vesicles might be guided to the vicinity of points of exocytosis defined by beta -neurexins via the interaction between rabphilin3a-CASK-beta -neurexins. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B,V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | SYNAPTIC VESICLE EXOCYTOSIS ; NEUROTRANSMITTER RELEASE ; MEMBRANE-FUSION ; CASK/LIN-2 ; FAMILY ; CELLS ; SYNAPTOTAGMIN ; SECRETION ; MOLECULES ; BINDING |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000169120900008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2728]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Y,Luan, ZD,Liu, AH,et al. The scaffolding protein CASK mediates the interaction between rabphilin3a and beta-neurexins[J]. FEBS LETTERS,2001,497(1):99-102. |
| APA | Zhang, Y,Luan, ZD,Liu, AH,&Hu, GX.(2001).The scaffolding protein CASK mediates the interaction between rabphilin3a and beta-neurexins.FEBS LETTERS,497(1),99-102. |
| MLA | Zhang, Y,et al."The scaffolding protein CASK mediates the interaction between rabphilin3a and beta-neurexins".FEBS LETTERS 497.1(2001):99-102. |
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