Mouse nestin protein localizes in growth cones of P19 neurons and cerebellar granule cells
文献类型：期刊论文
| 作者 | Yan, Y; Yang, J; Bian, W; Jing, NH |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2001 |
| 卷号 | 302期号:1页码:89-92 |
| 关键词 | growth cone nestin growth-associated protein-43 P19 neurons cerebellar granule cells |
| 通讯作者 | Jing, NH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | The neuronal growth cone, a highly motile structure at the distal tip of growing axons, contains filamentous actin and microtubules as its main cytoskeletal components. Using immunocytochemistry, we observed that nestin, which is the predominant intermediate filament protein in neuroepithelial cells and young neurons of the developing brain, appears to be strongly expressed in neurites and growth cones of neurons differentiating from P19 embryonic carcinoma cells in vitro. Double-staining of nestin and microtubule-associated protein-2 as well as nestin and growth-associated protein-43 revealed that nestin protein localizes in neurites and the central regions of growth cones of primary cultures of cerebellar granule cells from postnatal day 6 mice. These results suggest a role for nestin in growth cone guidance during axon elongation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | INTERMEDIATE FILAMENT PROTEIN ; ORGANIZATION ; NEUROFILAMENT ; IDENTIFICATION ; EXPRESSION ; ELONGATION ; DYNAMICS ; GUIDANCE ; SYSTEM ; ACTIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000168139600007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2729]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yan, Y,Yang, J,Bian, W,et al. Mouse nestin protein localizes in growth cones of P19 neurons and cerebellar granule cells[J]. NEUROSCIENCE LETTERS,2001,302(1):89-92. |
| APA | Yan, Y,Yang, J,Bian, W,&Jing, NH.(2001).Mouse nestin protein localizes in growth cones of P19 neurons and cerebellar granule cells.NEUROSCIENCE LETTERS,302(1),89-92. |
| MLA | Yan, Y,et al."Mouse nestin protein localizes in growth cones of P19 neurons and cerebellar granule cells".NEUROSCIENCE LETTERS 302.1(2001):89-92. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。