Kringle 1 of human hepatocyte growth factor inhibits bovine aortic endothelial cell proliferation stimulated by basic fibroblast growth factor and causes cell apoptosis
文献类型：期刊论文
| 作者 | Xin, L; Xu, R; Zhang, Q; Li, TP; Gan, RB |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2000 |
| 卷号 | 277期号:1页码:186-190 |
| 关键词 | kringle hepatocyte growth factor angiostatin angiogenesis inhibitor apoptosis |
| 通讯作者 | Gan, RB (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, POB 55,320 Yue Yang Rd, Shanghai 200031, Peoples R China., |
| 英文摘要 | Hepatocyte growth factor (HGF), also known as scatter factor, is a mesenchymal or stromal-derived mediator with angiogenic activity. There are four kringle domains in its amino terminus. They display considerable sequence similarity with those of angiostatin, an angiogenesis inhibitor. We now describe that the recombinant kringle1 of HGF (HGFK1) inhibits bovine aortic endothelial (BAE) cell proliferation stimulated by basic fibroblast growth factor in a dose-dependent manner, with an ED50 of approximately 0.7 mug/ml, while ED50 of angiostatin is 3 mug/ml, Treatment of BAE cell with HGFK1 caused cell apoptosis, This report thus constitutes the first demonstration that kringle1 of HGF is a selective inhibitor for BAE cell proliferation stimulated by bFGF. (C) 2000 Academic Press. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | HUMAN ANGIOSTATIN ; ANGIOGENESIS ; APOLIPOPROTEIN(A) ; EXPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000090070400032 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2736]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xin, L,Xu, R,Zhang, Q,et al. Kringle 1 of human hepatocyte growth factor inhibits bovine aortic endothelial cell proliferation stimulated by basic fibroblast growth factor and causes cell apoptosis[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2000,277(1):186-190. |
| APA | Xin, L,Xu, R,Zhang, Q,Li, TP,&Gan, RB.(2000).Kringle 1 of human hepatocyte growth factor inhibits bovine aortic endothelial cell proliferation stimulated by basic fibroblast growth factor and causes cell apoptosis.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,277(1),186-190. |
| MLA | Xin, L,et al."Kringle 1 of human hepatocyte growth factor inhibits bovine aortic endothelial cell proliferation stimulated by basic fibroblast growth factor and causes cell apoptosis".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 277.1(2000):186-190. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。