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NF-kappa B regulates the LPS-induced expression of interleukin 12 p40 in murine peritoneal macrophages: Roles of PKC, PKA, ERK, p38 MAPK, and proteasome
文献类型：期刊论文
| 作者 | Zhang, JS; Feng, WG; Li, CL; Wang, XY; Chang, ZL |
| 刊名 | CELLULAR IMMUNOLOGY
 |
| 出版日期 | 2000 |
| 卷号 | 204期号:1页码:38-45 |
| 关键词 | signal transduction transcription factors cytokines |
| 通讯作者 | Chang, ZL (reprint author), Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Lab Immune Signal Transduct, Shanghai 200031, Peoples R China., |
| 英文摘要 | NF-kappa B plays a critical role in coordinating the control of gene expression during monocyte/macrophage activation. In this report we describe our investigation of the mechanisms of LPS-induced NF-kappa B activation and IL-12 expression in murine peritoneal suppressor macrophages. Treatment of these macrophages with LPS induced I kappa B alpha degradation and NF-kappa B activation. EMSAs demonstrated that NF-kappa B bound to a cis-acting element located in the murine IL-12 p40 promoter. LPS signal transduction has been shown to involve a variety of signal pathways. The results in this paper indicate that LPS-induced NF-kappa B binding activity was independent of PKC, PHA, ERK, and p38 MAPK, but was regulated by proteasome. Furthermore, Proteasome Inhibitor I abolished the LPS-induced mRNA expression of IL-12 p35 and p40, and SB203580 reduced these mRNA levels, whereas the blockade of PKC, PKA, and ERK had little effect. These data demonstrate that the LPS-induced activation of proteasome I kappa B NF-kappa B and p38 MAPK signal pathways regulate the IL-12 expression in murine peritoneal suppressor macrophages. (C) 2000 Academic Press. |
| 学科主题 | Cell Biology; Immunology |
| 类目[WOS] | Cell Biology ; Immunology |
| 关键词[WOS] | ACTIVATED PROTEIN-KINASE ; TRANSCRIPTION FACTORS ; SIGNAL-TRANSDUCTION ; GENE-EXPRESSION ; REL PROTEINS ; CELLS ; LIPOPOLYSACCHARIDE ; SUBUNIT ; COMPLEX ; PHOSPHORYLATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000089803200005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2738]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, JS,Feng, WG,Li, CL,et al. NF-kappa B regulates the LPS-induced expression of interleukin 12 p40 in murine peritoneal macrophages: Roles of PKC, PKA, ERK, p38 MAPK, and proteasome[J]. CELLULAR IMMUNOLOGY,2000,204(1):38-45. |
| APA | Zhang, JS,Feng, WG,Li, CL,Wang, XY,&Chang, ZL.(2000).NF-kappa B regulates the LPS-induced expression of interleukin 12 p40 in murine peritoneal macrophages: Roles of PKC, PKA, ERK, p38 MAPK, and proteasome.CELLULAR IMMUNOLOGY,204(1),38-45. |
| MLA | Zhang, JS,et al."NF-kappa B regulates the LPS-induced expression of interleukin 12 p40 in murine peritoneal macrophages: Roles of PKC, PKA, ERK, p38 MAPK, and proteasome".CELLULAR IMMUNOLOGY 204.1(2000):38-45. |
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