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Investigating 42 candidate orthologous protein groups by molecular evolutionary analysis on genome scale
文献类型：期刊论文
| 作者 | Xie, T; Ding, DF |
| 刊名 | GENE
 |
| 出版日期 | 2000 |
| 卷号 | 261期号:2页码:305-310 |
| 关键词 | ortholog paralog phylogenetic method comparative genomics |
| 通讯作者 | Ding, DF (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China., |
| 英文摘要 | It is one of key problems for comparative genomics to accurately identify orthologous genes/proteins. Here 42 quartettes of human, yeast Saccharomyces cerevisiae, nematode Caenorhabditis elegans, and fruit fly Drosophila melanogaster candidate orthologs, defined by using similarity-based highest hit criteria (Mushegian et al., 1998 Genome Res. 8. 590-598), were reconsidered according to molecular evolutionary analysis. We found that only 14 of the 42 candidate orthologous groups can be identified to have truly one-to-one orthologous relationships, whereas other groups were characterized by one (many)-to-many orthologous relationships or even more complex scenarios involving gene duplications and/or gene losses. The result could imply that the classical one-to-one orthology might be not as common as typically accepted and automated similarity-based methods should be used with caution when accurate orthology/paralogy discrimination is required. (C) 2000 Elsevier Science B.V. All rights reserved. |
| 学科主题 | Genetics & Heredity |
| 类目[WOS] | Genetics & Heredity |
| 关键词[WOS] | RECONCILED TREES ; GENES ; PHYLOGENIES ; SEQUENCES ; NEMATODE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000166956600014 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/2739]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xie, T,Ding, DF. Investigating 42 candidate orthologous protein groups by molecular evolutionary analysis on genome scale[J]. GENE,2000,261(2):305-310. |
| APA | Xie, T,&Ding, DF.(2000).Investigating 42 candidate orthologous protein groups by molecular evolutionary analysis on genome scale.GENE,261(2),305-310. |
| MLA | Xie, T,et al."Investigating 42 candidate orthologous protein groups by molecular evolutionary analysis on genome scale".GENE 261.2(2000):305-310. |
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