Nanoparticle-mediated delivery of Neurotoxin-II to the brain with intranasal administration: an effective strategy to improve antinociceptive activity of Neurotoxin
文献类型：期刊论文
| 作者 | Ruan, Yeping1; Yao, Li1; Zhang, Bingbing1; Zhang, Shuijuan1; Guo, Jianyou2 |
| 刊名 | DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
 |
| 出版日期 | 2012 |
| 卷号 | 38期号:1页码:123-128 |
| 关键词 | Polysorbate-80 nasal delivery blood-brain barrier central nervous system drug loading |
| ISSN号 | 0363-9045 |
| 产权排序 | 2 |
| 通讯作者 | Ruan, YP (reprint author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China. |
| 英文摘要 | Background: Neurotoxin-II (NT-II), an analgesic peptide which was separated from the venom of Naja naja atra, is endowed an exceptional specificity of action that block transmission of the nerve impulse by binding to the acetylcholine receptor in the membrane. However, it has limited permeability across the blood-brain barrier (BBB) after intravenously (i.v.) injection. |
| 学科主题 | Medical psychology |
| 收录类别 | SCI |
| 项目简介 | This project was supported by Nature Sciences Foundation of Zhejiang (Y2101127). The authors declare that they have no competing interests. |
| 语种 | 英语 |
| WOS记录号 | WOS:000297470800014 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/12866]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China 2.Chinese Acad Sci Beijing, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ruan, Yeping,Yao, Li,Zhang, Bingbing,et al. Nanoparticle-mediated delivery of Neurotoxin-II to the brain with intranasal administration: an effective strategy to improve antinociceptive activity of Neurotoxin[J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,2012,38(1):123-128. |
| APA | Ruan, Yeping,Yao, Li,Zhang, Bingbing,Zhang, Shuijuan,&Guo, Jianyou.(2012).Nanoparticle-mediated delivery of Neurotoxin-II to the brain with intranasal administration: an effective strategy to improve antinociceptive activity of Neurotoxin.DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,38(1),123-128. |
| MLA | Ruan, Yeping,et al."Nanoparticle-mediated delivery of Neurotoxin-II to the brain with intranasal administration: an effective strategy to improve antinociceptive activity of Neurotoxin".DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 38.1(2012):123-128. |
入库方式： OAI收割
来源：心理研究所
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