Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study
文献类型：期刊论文
| 作者 | Zhang KunLin1 ; Zhang LiuYan1,2; Zhang WeiNa1,2; Wang Jing1
|
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2011-11-01 |
| 卷号 | 56期号:32页码:3398-3402 |
| 关键词 | schizophrenia (SZ) genome-wide association study (GWAS) pathway-based analysis (PBA) bipolar disorder (BD) |
| ISSN号 | 1001-6538 |
| 产权排序 | 1 |
| 通讯作者 | Wang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China. |
| 英文摘要 | Schizophrenia (SZ) is an inheritable complex mental disease. There have been several genome-wide association studies (GWASs) of SZ to identify novel genetic susceptibility factors. To further interpret SZ GWASs, pathway-based analysis (PBA), which considers the combined effect of variants and identifies pathways associated with traits, provides a feasible solution to discover the biological function and mechanism of SZ. Furthermore, to investigate the common pathways between SZ and bipolar disorder (BD) will help explore common mechanism between psychiatric phenotypes. We performed a PBA, called improved gene set enrichment analysis (i-GSEA), on 3 independent GWASs of SZ to identify pathways associated with SZ. The results were further compared to the BD-associated pathways identified by i-GSEA for 2 BD GWASs and from literature reports. Our analysis identified a highly statistically significant association between SZ and pathway 'substrate specific channel activity' in all 3 SZ GWASs (false discovery rate (FDR) < 0.05). This association has not been reported elsewhere before. This pathway was also identified by PBA for 2 independent BD GWASs. Our results suggest that pathway 'substrate specific channel activity' is statistically significantly associated with SZ, and SZ and BD share the common biological function and mechanism represented by this pathway. |
| 学科主题 | Abnormal psychology |
| 收录类别 | SCI |
| 项目简介 | This work was supported by the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8) and Project for Young Scientists Fund, Institute of Psychology, Chinese Academy of Sciences (O9CX115011). |
| 原文出处 | http://www.medlive.cn/uploadfile/2011/1011/20111011092514161.pdf |
| 语种 | 英语 |
| WOS记录号 | WOS:000296641800008 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/12886]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang KunLin,Zhang LiuYan,Zhang WeiNa,et al. Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study[J]. CHINESE SCIENCE BULLETIN,2011,56(32):3398-3402. |
| APA | Zhang KunLin,Zhang LiuYan,Zhang WeiNa,&Wang Jing.(2011).Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study.CHINESE SCIENCE BULLETIN,56(32),3398-3402. |
| MLA | Zhang KunLin,et al."Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study".CHINESE SCIENCE BULLETIN 56.32(2011):3398-3402. |
入库方式： OAI收割
来源：心理研究所
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