PERSONALIZED TREATMENT OF ADULT DEPRESSION: MEDICATION, PSYCHOTHERAPY, OR BOTH? A SYSTEMATIC REVIEW
文献类型：期刊论文
| 作者 | Cuijpers, Pim1,2; Reynolds, Charles F., III3; Donker, Tara1,2; Li, Juan4 ; Andersson, Gerhard5,6; Beekman, Aartjan7
|
| 刊名 | DEPRESSION AND ANXIETY
 |
| 出版日期 | 2012-10-01 |
| 卷号 | 29期号:10页码:855-864 |
| 关键词 | antidepressants clinical trials depression dysthymic disorder treatment |
| ISSN号 | 1091-4269 |
| 产权排序 | 4 |
| 通讯作者 | Cuijpers, P (reprint author), Vrije Univ Amsterdam, Dept Clin Psychol, Boechorststr 1, NL-1081 BT Amsterdam, Netherlands. |
| 英文摘要 | Background Personalized medicine aims to identify which characteristics of an individual predict the outcome of a specific treatment, in order to get a better match between the individual and the treatment received. We conducted a systematic review and meta-analysis of randomized trials comparing two treatments directly in a group of patients with a specific characteristic. Methods We searched relevant studies from bibliographical databases and included trials comparing (1) medication with psychotherapy, (2) medication with combined treatment, and (3) psychotherapy with combined treatment, in specific target groups (a) with a predefined sociodemographic characteristic, (b) a specific type of depression, (c) a comorbid mental or somatic disorder, or (d) from a specific setting (outpatients, primary care). Results We included 52 studies with 4,734 depressed patients. In these studies, 20 characteristics of the target groups were examined. The results showed that medication is probably the best treatment for dysthymia, and combined treatments are more effective in depressed outpatients, as well as in depressed older adults. However, in order to examine the 20 characteristics in the three categories of comparisons, 254 studies would be needed for having sufficient statistical power to show an effect size of g = 0.5. Currently, only 20.1% of these studies have been conducted. Conclusions Although a considerable number of studies have compared medication, psychotherapy, and combined treatments, and some preliminary results are useful for deciding which treatment is best for which patient, the development of personalized treatment of depression has only just begun. |
| 学科主题 | Personality psychology,Cognitive neuroscience |
| 收录类别 | SSCI |
| 原文出处 | http://onlinelibrary.wiley.com/doi/10.1002/da.21985/epdf |
| 语种 | 英语 |
| WOS记录号 | WOS:000309394600004 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/12893]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Vrije Univ Amsterdam, Dept Clin Psychol, NL-1081 BT Amsterdam, Netherlands 2.Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands 3.Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA 4.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China 5.Linkoping Univ, Swedish Inst Disabil Res, Dept Behav Sci & Learning, S-58183 Linkoping, Sweden 6.Karolinska Inst, Psychiat Sect, Dept Clin Neurosci, Stockholm, Sweden 7.Vrije Univ Amsterdam, Med Ctr Amsterdam, Dept Psychiat, Amsterdam, Netherlands |
| 推荐引用方式 GB/T 7714 | Cuijpers, Pim,Reynolds, Charles F., III,Donker, Tara,et al. PERSONALIZED TREATMENT OF ADULT DEPRESSION: MEDICATION, PSYCHOTHERAPY, OR BOTH? A SYSTEMATIC REVIEW[J]. DEPRESSION AND ANXIETY,2012,29(10):855-864. |
| APA | Cuijpers, Pim,Reynolds, Charles F., III,Donker, Tara,Li, Juan,Andersson, Gerhard,&Beekman, Aartjan.(2012).PERSONALIZED TREATMENT OF ADULT DEPRESSION: MEDICATION, PSYCHOTHERAPY, OR BOTH? A SYSTEMATIC REVIEW.DEPRESSION AND ANXIETY,29(10),855-864. |
| MLA | Cuijpers, Pim,et al."PERSONALIZED TREATMENT OF ADULT DEPRESSION: MEDICATION, PSYCHOTHERAPY, OR BOTH? A SYSTEMATIC REVIEW".DEPRESSION AND ANXIETY 29.10(2012):855-864. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。