Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources
文献类型：期刊论文
| 作者 | Chang, Suhua1,2 ; Zhang, Weina1,2; Gao, Lei1,2; Wang, Jing1
|
| 刊名 | PROTEIN & CELL
 |
| 出版日期 | 2012-07-01 |
| 卷号 | 3期号:7页码:526-534 |
| ISSN号 | 1674-800X |
| 关键词 | gene prioritization attention deficit hyperactivity disorder candidate genes multiple data sources |
| 通讯作者 | Wang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China. |
| 产权排序 | 1 |
| 英文摘要 | Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable psychiatric disorder characterized by hyperactivity, inattention and increased im-pulsivity. In recent years, a large number of genetic studies for ADHD have been published and related genetic data has been accumulated dramatically. To provide researchers a comprehensive ADHD genetic resource, we previously developed the first genetic database for ADHD (ADHDgene). The abundant genetic data provides novel candidates for further study. Meanwhile, it also brings new challenge for selecting promising candidate genes for replication and verification research. In this study, we surveyed the computational tools for candidate gene prioritization and selected five tools, which integrate multiple data sources for gene prioritization, to prioritize ADHD candidate genes in ADHDgene. The prioritization analysis resulted in 16 prioritized candidate genes, which are mainly involved in several major neurotransmitter systems or in nervous system development pathways. Among these genes, nervous system development related genes, especially SNAP25, STX1A and the gene-gene interactions related with each of them deserve further investigations. Our results may provide new insight for further verification study and facilitate the exploration of pathogenesis mechanism of ADHD. |
| 学科主题 | Cognitive psychology |
| 收录类别 | SCI |
| 项目简介 | This work was supported by Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences. |
| 语种 | 英语 |
| WOS记录号 | WOS:000310531200007 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/12902]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chang, Suhua,Zhang, Weina,Gao, Lei,et al. Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources[J]. PROTEIN & CELL,2012,3(7):526-534. |
| APA | Chang, Suhua,Zhang, Weina,Gao, Lei,&Wang, Jing.(2012).Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources.PROTEIN & CELL,3(7),526-534. |
| MLA | Chang, Suhua,et al."Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources".PROTEIN & CELL 3.7(2012):526-534. |
入库方式： OAI收割
来源：心理研究所
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