Reduced recruitment of orbitofrontal cortex to human social chemosensory cues in social anxiety
文献类型：期刊论文
| 作者 | Zhou, Wen2 ; Hou, Ping3,4; Zhou, Yuxiang3; Chen, Denise1
|
| 刊名 | NEUROIMAGE
 |
| 出版日期 | 2011-04-01 |
| 卷号 | 55期号:3页码:1401-1406 |
| ISSN号 | 1053-8119 |
| 产权排序 | 1 |
| 通讯作者 | Chen, D (reprint author), Rice Univ, Dept Psychol MS 25, 6100 Main St, Houston, TX 77005 USA. |
| 英文摘要 | Social anxiety refers to the prevalent and debilitating experience of fear and anxiety of being scrutinized in social situations. It originates from both learned (e.g. adverse social conditioning) and innate (e.g. shyness) factors. Research on social anxiety has traditionally focused on negative emotions induced by visual and auditory social cues in socially anxious clinical populations, and posits a dysfunctional orbitofrontal-amygdala circuit as a primary etiological mechanism. Yet as a trait, social anxiety is independent of one's specific emotional state. Here we probe the neural substrate of intrinsic social anxiety by employing a unique type of social stimuli, airborne human social chemosensory cues that are inherently social, ubiquitously present, and yet operating below verbal awareness. We show that the adopted social chemosensory cues were not perceived to be human-related, did not differentially bias self-report of anxiety or autonomic nervous system responses, yet individuals with elevated social anxiety demonstrated a reduced recruitment of the orbitofrontal cortex to social chemosensory cues. No reciprocal activity in the amygdala was observed. Our findings point to an intrinsic neural substrate underlying social anxiety that is not associated with prior adverse social conditioning, thereby providing the first neural evidence for the inherent social aspect of this enigmatic phenomenon. (C) 2011 Elsevier Inc. All rights reserved. |
| 学科主题 | Emotional psychology，Social psychology |
| 收录类别 | SCI ; SSCI |
| 项目简介 | This work was supported by NIH R03 DC4956. The purchase of the MRI scanner was partially funded by NCRR/NIH grant # S10RR19186-01. We thank Vips Patel for the assistance with fMRI data collection, and Jay Gottfried, Wen Li, Gang Chen, Michael S. Beauchamp for helpful discussions. |
| 原文出处 | http://zhouw.psych.ac.cn/Zhou.Hou.Zhou.Chen.NeuroImage.2011.pdf |
| 语种 | 英语 |
| WOS记录号 | WOS:000288313800052 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/12911]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Rice Univ, Dept Psychol MS 25, Houston, TX 77005 USA 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Univ Texas Med Sch Houston, Dept Diagnost & Intervent Imaging, Houston, TX 77030 USA 4.Univ Texas MD Anderson Canc Ctr, Dept Imaging Phys, Houston, TX 77030 USA |
| 推荐引用方式 GB/T 7714 | Zhou, Wen,Hou, Ping,Zhou, Yuxiang,et al. Reduced recruitment of orbitofrontal cortex to human social chemosensory cues in social anxiety[J]. NEUROIMAGE,2011,55(3):1401-1406. |
| APA | Zhou, Wen,Hou, Ping,Zhou, Yuxiang,&Chen, Denise.(2011).Reduced recruitment of orbitofrontal cortex to human social chemosensory cues in social anxiety.NEUROIMAGE,55(3),1401-1406. |
| MLA | Zhou, Wen,et al."Reduced recruitment of orbitofrontal cortex to human social chemosensory cues in social anxiety".NEUROIMAGE 55.3(2011):1401-1406. |
入库方式： OAI收割
来源：心理研究所
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