Highly Efficient Synthesis of Two Hyaluronan Trisaccharide Analogues for Potential Hyaluronic Acid Synthases Inhibitors
文献类型：期刊论文
| 作者 | Wei Guo-Hua ; Du Yu-Guo ; Matta, Khushi L. |
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2009-11-10 |
| 卷号 | 30期号:11页码:2199-2203 |
| 关键词 | Hyaluronan Hyaluronic acid synthase Inhibitor 2-Naphthylmethyl(NAP) |
| 中文摘要 | The syntheses of two hyaluronan trisaccharide analogues, naphthyl O-(3-methoxy-beta-D-glueopyranosyluronic acid)-(1,3)-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-(1, 4)-O-beta-D-glueopyranosyluronic acid and naphthyl O-(3-methoxy-2-acetamido-2-deoxy-beta-D-glueopyranosyl)-(1 4)-O-(beta-D-glucopyranosyluronic acid)-(1,3)-O-2-acetamido-2-deoxy-beta-glucopyranoside, were described. Construction of the target molecules was achieved through a combination of BF(3)center dot Et(2)O/toluene system and trichloroacetimidate glycosylation methodology. This is the first report on the synthesis of the 3-methoxyl derivatives, which represent the smallest fragments that incorporate all the structural features of polymeric hyaluronan and can be used for potential hyaluronic acid synthases inhibitors. |
| WOS记录号 | WOS:000272832200020 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/21509]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wei Guo-Hua,Du Yu-Guo,Matta, Khushi L.. Highly Efficient Synthesis of Two Hyaluronan Trisaccharide Analogues for Potential Hyaluronic Acid Synthases Inhibitors[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2009,30(11):2199-2203. |
| APA | Wei Guo-Hua,Du Yu-Guo,&Matta, Khushi L..(2009).Highly Efficient Synthesis of Two Hyaluronan Trisaccharide Analogues for Potential Hyaluronic Acid Synthases Inhibitors.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,30(11),2199-2203. |
| MLA | Wei Guo-Hua,et al."Highly Efficient Synthesis of Two Hyaluronan Trisaccharide Analogues for Potential Hyaluronic Acid Synthases Inhibitors".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 30.11(2009):2199-2203. |
入库方式： OAI收割
来源：生态环境研究中心
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