Metabolism, Toxicity, and Biomonitoring of Arsenic Species
文献类型：期刊论文
| 作者 | Chen Baowei ; Hua, Naramandura ; Lue Meiling ; Le, X. Chris |
| 刊名 | PROGRESS IN CHEMISTRY
 |
| 出版日期 | 2009-03 |
| 卷号 | 21期号:1页码:474-482 |
| 关键词 | arsenic speciation biomarkers metabolism biomethylation reactive oxygen species protein interaction environmental carcinogenesis exposure assessment environmental toxicology |
| 中文摘要 | Arsenic is the most common and hazardous environmental contaminant, affecting millions of people around the world. The mechanisms of action responsible for the wide range of chronic health effects are complicated and remain to be understood. This review article describes several recent studies on metabolism, toxicity, and biomonitoring of arsenic species. Biomethylation is the most common process involved in the metabolism of arsenicals, producing mono-, di-, and tri-methyl arsenic species. Ability to biomethylate arsenic is related to the expression of methyltransferases, e. g., As(III)-S-adenosylmethionine methyltransferase (AS3MT). Many of the arsenic metabolites have been detected in body fluids, tissues, and cell culture experiments. Much recent research has focused on the understanding of metabolism and toxicity of the various arsenic species, aiming to delineate the biological processes and the particular arsenic species that are responsible for the observed health effects. Detailed studies on binding of arsenic to proteins help gain insight into arsenic retention and its effects on enzyme inhibition and protein expression. Biomonitoring of arsenic species in urine, blood, saliva, nail, and hair is useful for assessing overall exposure and for further improving understanding of tissue distribution, metabolism, and toxicity of arsenic species. |
| WOS记录号 | WOS:000264790400020 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/21535]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen Baowei,Hua, Naramandura,Lue Meiling,et al. Metabolism, Toxicity, and Biomonitoring of Arsenic Species[J]. PROGRESS IN CHEMISTRY,2009,21(1):474-482. |
| APA | Chen Baowei,Hua, Naramandura,Lue Meiling,&Le, X. Chris.(2009).Metabolism, Toxicity, and Biomonitoring of Arsenic Species.PROGRESS IN CHEMISTRY,21(1),474-482. |
| MLA | Chen Baowei,et al."Metabolism, Toxicity, and Biomonitoring of Arsenic Species".PROGRESS IN CHEMISTRY 21.1(2009):474-482. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。