Quantum Dots Enhanced Ultrasensitive Detection of DNA Adducts
文献类型：期刊论文
| 作者 | Wang, Zhixin ; Lu, Meiling ; Wang, Xiaoli ; Yin, Ruichuan ; Song, Yuling ; Le, X. Chris ; Wang, Hailin |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2009-12-15 |
| 卷号 | 81期号:24页码:10285-10289 |
| 中文摘要 | Here we demonstrate that quantum dots (QD) can greatly improve the ultrasensitive capillary electrophoresis-laser induced fluorescence immunoassay of trace anti-benzo(a)pyrene diol epoxide (BPDE)-DNA adducts from sensitivity to separation. We for the first time show that the target QD-antibody-DNA complex is not only effectively separated but also effectively focused by capillary electrophoresis. With the online laser-induced fluorescence detection coupled, the low limits of detection of 6.6 x 10(-21) mol in mass and 120 fM in concentration are achieved for BPDE-DNA adducts. The achieved ultrasensitivity allows for human exposure biomonitoring and shows promising applications of QD in various DNA analyses, including DNA damage. |
| WOS记录号 | WOS:000272562200057 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/21560]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wang, Zhixin,Lu, Meiling,Wang, Xiaoli,et al. Quantum Dots Enhanced Ultrasensitive Detection of DNA Adducts[J]. ANALYTICAL CHEMISTRY,2009,81(24):10285-10289. |
| APA | Wang, Zhixin.,Lu, Meiling.,Wang, Xiaoli.,Yin, Ruichuan.,Song, Yuling.,...&Wang, Hailin.(2009).Quantum Dots Enhanced Ultrasensitive Detection of DNA Adducts.ANALYTICAL CHEMISTRY,81(24),10285-10289. |
| MLA | Wang, Zhixin,et al."Quantum Dots Enhanced Ultrasensitive Detection of DNA Adducts".ANALYTICAL CHEMISTRY 81.24(2009):10285-10289. |
入库方式： OAI收割
来源：生态环境研究中心
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