Synthesis of oleanolic acid saponins mimicking components of Chinese folk medicine Di Wu
文献类型：期刊论文
| 作者 | Huang, Xing ; Cheng, Shuihong ; Du, Yuguo ; Bing, Feihong |
| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2009-07-06 |
| 卷号 | 344期号:10页码:1153-1158 |
| 关键词 | Saponin Apoptosis Natural product Chinese folk medicine Cytotoxicity |
| 中文摘要 | 3,28-Di-O-rhamnosylated oleanolic acid saponins, mimicking components of Chinese folk medicine Di Wu, have been designed and synthesized. one-pot glycosylation and 'inverse procedure' technologies have been applied thus significantly simplifying the preparation of desired saponins. The cytotoxic activity of compounds 3-O-[alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-xylopyranosyl]oleanolic acid 28-O-[alpha-L-rhamnopyranosyl-(1 -> 4)-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranosyl] ester (3), 3-O-[alpha-L-rhamnopyranosyl]oleanolic acid 28-O-[alpha-L-rhamnopyranosyl- (1 -> 4)-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranosyl] ester (4), 3-O-[alpha-L-rhamnopyranosyl]oleanolic acid 28-O-[alpha-L-rhamnopyranosyl] ester (5), and 3-O-[alpha-L-rhamnopyranosyl]oleanolic acid 28-O-[6-O-(alpha-L-rhamnopyranosyl)hexyl] ester (6) was preliminarily evaluated against HL-60 human promyelocytic leukemia cells. The natural saponin 3 and designed saponin 4 exhibited comparable moderate cytotoxic activity under our testing conditions. (C) 2009 Elsevier Ltd. All rights reserved. |
| WOS记录号 | WOS:000267728000001 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/21576]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Huang, Xing,Cheng, Shuihong,Du, Yuguo,et al. Synthesis of oleanolic acid saponins mimicking components of Chinese folk medicine Di Wu[J]. CARBOHYDRATE RESEARCH,2009,344(10):1153-1158. |
| APA | Huang, Xing,Cheng, Shuihong,Du, Yuguo,&Bing, Feihong.(2009).Synthesis of oleanolic acid saponins mimicking components of Chinese folk medicine Di Wu.CARBOHYDRATE RESEARCH,344(10),1153-1158. |
| MLA | Huang, Xing,et al."Synthesis of oleanolic acid saponins mimicking components of Chinese folk medicine Di Wu".CARBOHYDRATE RESEARCH 344.10(2009):1153-1158. |
入库方式： OAI收割
来源：生态环境研究中心
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