The first chemical synthesis of novel MeO-3-GlcUA derivative of hyaluronan-based disaccharide to elucidate the catalytic mechanism of hyaluronic acid synthases (HASs)
文献类型：期刊论文
| 作者 | Wei, Guohua ; Kumar, Vipin ; Xue, Jun ; Locke, Robert D. ; Matta, Khushi L. |
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2009-11-25 |
| 卷号 | 50期号:47页码:6543-6545 |
| 关键词 | MeO-3-GlcUA Hyaluronic acid synthases (HASs) Oligosaccharides Phosphorylation |
| 中文摘要 | The first chemical synthesis of MeO-3-GluUA beta(1 -> 3)GlcNAc-UDP to elucidate the catalytic mechanism of hyalyionic acid synthases (HASS) is described. Construction of the desired beta(1 -> 3)-linked disaccharide 10 was achieved very efficiently by Coupling MeO-3-GlcUA donor 3 with the suitable protected GlCnt(10C) acceptor 4 using BF(3) Et(2)O as Lewis acid Chemoselective removal of anomeric NAP, phosphorylation, hydrogenation, coupling with UMP-morpholidate, and finally complete deprotection gave the target compound 1 in good yield (C) 2009 Elsevier Ltd All rights reserved |
| WOS记录号 | WOS:000271280200031 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/21578]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wei, Guohua,Kumar, Vipin,Xue, Jun,et al. The first chemical synthesis of novel MeO-3-GlcUA derivative of hyaluronan-based disaccharide to elucidate the catalytic mechanism of hyaluronic acid synthases (HASs)[J]. TETRAHEDRON LETTERS,2009,50(47):6543-6545. |
| APA | Wei, Guohua,Kumar, Vipin,Xue, Jun,Locke, Robert D.,&Matta, Khushi L..(2009).The first chemical synthesis of novel MeO-3-GlcUA derivative of hyaluronan-based disaccharide to elucidate the catalytic mechanism of hyaluronic acid synthases (HASs).TETRAHEDRON LETTERS,50(47),6543-6545. |
| MLA | Wei, Guohua,et al."The first chemical synthesis of novel MeO-3-GlcUA derivative of hyaluronan-based disaccharide to elucidate the catalytic mechanism of hyaluronic acid synthases (HASs)".TETRAHEDRON LETTERS 50.47(2009):6543-6545. |
入库方式： OAI收割
来源：生态环境研究中心
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