The Proteasome Is a Molecular Target of Environmental Toxic Organotins
文献类型：期刊论文
| 作者 | Shi, Guoqing ; Chen, Di ; Zhai, Guangshu ; Chen, Marina S. ; Cui, Qiuzhi Cindy ; Zhou, Qunfang ; He, Bin ; Dou, Q. Ping ; Jiang, Guibin |
| 刊名 | ENVIRONMENTAL HEALTH PERSPECTIVES
 |
| 出版日期 | 2009-03 |
| 卷号 | 117期号:3页码:379-386 |
| 关键词 | cell death molecular target organotins proteasome proteasome inhibitors TPT |
| 中文摘要 | BACKGROUND: Because of the vital importance of the proteasome pathway, chemicals affecting proteasome activity could disrupt essential cellular processes. Although the toxicity of organotins to both invertebrates and vertebrates is well known, the essential cellular target of organotins has not been well identified. We hypothesize that the proteasome is a molecular target of environmental toxic organotins. OBJECTIVES: Our goal was to test the above hypothesis by investigating whether organotins could inhibit the activity of purified and cellular proteasomes and, if so, the involved molecular mechanisms and downstream, events. RESULTS: We found that some toxic organotins [e.g., triphenyltin (TPT)] can potently and preferentially inhibit the chymotrypsin-like activity of purified 20S proteasomes and human breast cancer cellular 26S proteasomes. Direct binding of tin atoms to cellular proteasomes is responsible for the observed irreversible inhibition. Inhibition of cellular proteasomes by TPT in several human cell lines results in the accumulation of ubiquitinated proteins and natural proteasome target proteins, accompanied by induction of cell death. CONCLUSIONS: The proteasome is one of the molecular targets of environmental toxic organotins in human cells, and proteasome inhibition by organotins contributes to their cellular toxicity. |
| WOS记录号 | WOS:000263933600025 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/21580]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Shi, Guoqing,Chen, Di,Zhai, Guangshu,et al. The Proteasome Is a Molecular Target of Environmental Toxic Organotins[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2009,117(3):379-386. |
| APA | Shi, Guoqing.,Chen, Di.,Zhai, Guangshu.,Chen, Marina S..,Cui, Qiuzhi Cindy.,...&Jiang, Guibin.(2009).The Proteasome Is a Molecular Target of Environmental Toxic Organotins.ENVIRONMENTAL HEALTH PERSPECTIVES,117(3),379-386. |
| MLA | Shi, Guoqing,et al."The Proteasome Is a Molecular Target of Environmental Toxic Organotins".ENVIRONMENTAL HEALTH PERSPECTIVES 117.3(2009):379-386. |
入库方式： OAI收割
来源：生态环境研究中心
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