Determination of Perfluorinated Compounds in Human Blood Samples by High Performance Liquid Chromatography-Electrospray Tandem Mass Spectrometry
文献类型：期刊论文
| 作者 | Pan Yuan-Yuan; Shi Ya-Li; Cai Ya-Qi |
| 刊名 | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2008-10 |
| 卷号 | 36期号:10页码:1321-1326 |
| 关键词 | Perfluorinated compounds high performance liquid chromatography-electrospray ionization tandem mass spectrometry human blood |
| 英文摘要 | A sensitive method was established for the separation and determination of nine perfluorinated compounds (PFCs) in blood samples. Perfluorohexane sulfonate (PFHxS), perfluorohetanoic acid (PFHpA), perfluorooctanoate (PFOA), perfluorooctane sulfonat (PFOS), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecnaoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA) and perflouorotetradodecanoic acid(PFTA) were detected by high performance liquid chromatography/electrospray tandem mass spectrometry (HPLC ESI MS/MS) with C(18) reversed phase column in 15 min, using (13)C(4) labeled PFOS (MPFOS) as the internal standard. PFCs in the blood samples were further extracted with solid phase extraction cartridges after traditional MTBE extraction before injection. Four kinds of cartridges were tested, including RP, P, C(18) and HLB, then HLB cartridge was selected as the efficient adsorbent. A comparative study of two C(18) columns, Acclaim 120 (50 mm x 4.6 min, 3 mu m) and Acclaim 120 (250 mm x 4.6 mm, 5 mu m) column, were also performed. Both columns provided similar sensitivities, with the detection limits of 0.03 -0.8 mu g/L for real blood samples. The relative standard deviation of recoveries ranged from 3% to 11%. Finally, Acclaim 120 (250 mm x 4.6 mm, 5 mu m) column was chosen for its superiority of column capacity. With the optimal conditions, the recoveries of PFCs in blood samples ranged from 74.2% to 118.1%, with the exception of PFTA, which was only about 60% |
| WOS记录号 | WOS:000260694900003 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/21932]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Pan Yuan-Yuan,Shi Ya-Li,Cai Ya-Qi. Determination of Perfluorinated Compounds in Human Blood Samples by High Performance Liquid Chromatography-Electrospray Tandem Mass Spectrometry[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2008,36(10):1321-1326. |
| APA | Pan Yuan-Yuan,Shi Ya-Li,&Cai Ya-Qi.(2008).Determination of Perfluorinated Compounds in Human Blood Samples by High Performance Liquid Chromatography-Electrospray Tandem Mass Spectrometry.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,36(10),1321-1326. |
| MLA | Pan Yuan-Yuan,et al."Determination of Perfluorinated Compounds in Human Blood Samples by High Performance Liquid Chromatography-Electrospray Tandem Mass Spectrometry".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 36.10(2008):1321-1326. |
入库方式： OAI收割
来源：生态环境研究中心
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