Elemental selenium particles at nano-size (Nano-Se) are more toxic to Medaka (Oryzias latipes) as a consequence of hyper-accumulation of selenium: A comparison with sodium selenite
文献类型：期刊论文
| 作者 | Li, Hongcheng; Zhang, Jinsong; Wang, Thanh; Luo, Wenru; Zhou, Qunfang; Jiang, Guibin |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2008-09-29 |
| 卷号 | 89期号:4页码:251-256 |
| 关键词 | Nano-Se Selenite Medaka Nanotoxicology Hyper-accumulation |
| 英文摘要 | Recent studies have shown that elemental selenium particles at nano-size (Nano-Se) exhibited comparable bioavailability and less toxicity in mice and rats when compared to sodium selenite, selenomethinine and methylselenocysteine. However, little is known about the toxicity profile of Nano-Se in aquatic animals. In the present study, toxicities of Nano-Se and selenite in selenium-sufficient Medaka fish were compared. Selenium bioaccumulation and subsequent clearance in fish livers, gills, muscles and whole bodies were examined after 10 days of exposure to Nano-Se and selenite (100 mu g Se/L) and again after 7 days of deputation. Both forms of selenium exposure effectively increased selenium concentrations in the investigated tissues. Surprisingly, Nano-Se was found to be more hyper-accumulated in the liver compared to selenite with differences as high as sixfold. Selenium clearance of both Nano-Se and selenite occurred at similar ratios in whole bodies and muscles but was not rapidly cleared from livers and gills. Nano-Se exhibited strong toxicity for Medaka with an approximately fivefold difference in terms of LC50 compared to selenite. Nano-Se also caused larger effects on oxidative stress, most likely due to more hyper-accumulation of selenium in liver. The present study suggests that toxicity of nanoparticles can largely vary between different species and concludes that the evaluation of nanotoxicology should be carried out on a case-by-case basis. (C) 2008 Published by Elsevier B.V. |
| WOS记录号 | WOS:000260235900006 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/21943]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, Hongcheng,Zhang, Jinsong,Wang, Thanh,et al. Elemental selenium particles at nano-size (Nano-Se) are more toxic to Medaka (Oryzias latipes) as a consequence of hyper-accumulation of selenium: A comparison with sodium selenite[J]. AQUATIC TOXICOLOGY,2008,89(4):251-256. |
| APA | Li, Hongcheng,Zhang, Jinsong,Wang, Thanh,Luo, Wenru,Zhou, Qunfang,&Jiang, Guibin.(2008).Elemental selenium particles at nano-size (Nano-Se) are more toxic to Medaka (Oryzias latipes) as a consequence of hyper-accumulation of selenium: A comparison with sodium selenite.AQUATIC TOXICOLOGY,89(4),251-256. |
| MLA | Li, Hongcheng,et al."Elemental selenium particles at nano-size (Nano-Se) are more toxic to Medaka (Oryzias latipes) as a consequence of hyper-accumulation of selenium: A comparison with sodium selenite".AQUATIC TOXICOLOGY 89.4(2008):251-256. |
入库方式： OAI收割
来源：生态环境研究中心
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