The acute lethality and endocrine effect of 1,2,3,7,8-PeCDD in juvenile goldfish (Carassius auratus) in vivo
文献类型：期刊论文
| 作者 | Xiao Feng
|
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA
 |
| 出版日期 | 2008 |
| 卷号 | 20期号:2页码:240-245 |
| 关键词 | 1 goldfish endocrine effect vitellogenin (Vtg) acute lethality ELISA 2 3 7 8-PeCDD |
| 英文摘要 | 1,2,3,7,8-PeCDD was administrated to juvenile goldfish (Carassius auratus) by peritoneal injections to explore the acute lethality and endocrine effects of 1,2,3,7,8-PeCDD in vivo. The value of acute median lethal dosage (LD50) of 1,2,3,7,8-PeCDD was determined in acute lethality tests. The endocrine effect of 1,2,3,7,8-PeCDD, whose exposed concentrations were determined based on the LD50 (1.84 mg/kg), was studied by measuring the plasma vitellogenin (Vtg) content in juvenile male goldfish with enzyme-linked immunosorbent assays (ELISA). Due to its significant induction of the plasma Vtg after one week's exposure in vivo in the 1/2 LD50 and LD30 groups, 1,2,3,7,8-PeCDD might be one of the important contributors to the estrogenic effect of PCDDs in the environment. The values of 1/2 LD50 and LD30 were within the range of the effective dosages of 1,2,3,7,8-PeCDD, indicating that there was a certain relationship between the estrogenic effective dosages and the LD50. |
| WOS记录号 | WOS:000253009000018 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/22006]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Xiao Feng. The acute lethality and endocrine effect of 1,2,3,7,8-PeCDD in juvenile goldfish (Carassius auratus) in vivo[J]. JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,2008,20(2):240-245. |
| APA | Xiao Feng.(2008).The acute lethality and endocrine effect of 1,2,3,7,8-PeCDD in juvenile goldfish (Carassius auratus) in vivo.JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,20(2),240-245. |
| MLA | Xiao Feng."The acute lethality and endocrine effect of 1,2,3,7,8-PeCDD in juvenile goldfish (Carassius auratus) in vivo".JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA 20.2(2008):240-245. |
入库方式： OAI收割
来源：生态环境研究中心
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