Effects of exposure to acetochlor on the expression of thyroid hormone related genes in larval and adult rare minnow (Gobiocypris rarus)
文献类型：期刊论文
| 作者 | Li, Wei ; Zha, Jinmiao ; Li, Zhaoli ; Yang, Lihua ; Wang, Zijian |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2009-08-31 |
| 卷号 | 94期号:2页码:87-93 |
| 关键词 | Acetochlor Deiodinases Malic enzyme Thyroid hormone disruption Rare minnow (Gobiocypris rarus) |
| 中文摘要 | Acetochlor is a commonly used herbicide in agricultural environments, which can accelerate T(3)-induced metamorphosis in amphibians. However, effects of acetochlor on the thyroid system in fish are still unclear at environmentally relevant concentrations. In this study, expression profiles of thyroid hormone receptor alpha (tr alpha), deiodinase (d1 and d2), malic enzyme (me), and sodium iodide symporter (nis) genes were determined in larval and adult rare minnow (Gobiocypris rarus) after exposure to different levels of acetochlor (20, 200, and 2000 ng/l) for 21 days, respectively. Furthermore, plasma thyroid hormones (THs) levels in adults were evaluated simultaneously. The results showed that d1, d2, me, and nis mRNA levels were significantly down-regulated in the larvae. Similar expression changes of these genes in female brains were found. However, in adult livers, these gene expressions had no significantly effects, except the tree mRNA level significantly up-regulated. These results indicated that exposure to acetochlor could result in tissue-specific alternative expression of TH-related genes in adults. Moreover, the expression of d2 and me showed a positive correlation with plasma T(4) levels in female brains. Therefore, larval development and adult brain of rare minnow could be affected by acetochlor at environmentally relevant concentrations. (C) 2009 Elsevier B.V. All rights reserved. |
| WOS记录号 | WOS:000270291300002 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/21670]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, Wei,Zha, Jinmiao,Li, Zhaoli,et al. Effects of exposure to acetochlor on the expression of thyroid hormone related genes in larval and adult rare minnow (Gobiocypris rarus)[J]. AQUATIC TOXICOLOGY,2009,94(2):87-93. |
| APA | Li, Wei,Zha, Jinmiao,Li, Zhaoli,Yang, Lihua,&Wang, Zijian.(2009).Effects of exposure to acetochlor on the expression of thyroid hormone related genes in larval and adult rare minnow (Gobiocypris rarus).AQUATIC TOXICOLOGY,94(2),87-93. |
| MLA | Li, Wei,et al."Effects of exposure to acetochlor on the expression of thyroid hormone related genes in larval and adult rare minnow (Gobiocypris rarus)".AQUATIC TOXICOLOGY 94.2(2009):87-93. |
入库方式： OAI收割
来源：生态环境研究中心
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