Indirect Photodegradation of Amine Drugs in Aqueous Solution under Simulated Sunlight
文献类型：期刊论文
| 作者 | Chen, Yong ; Hu, Chun ; Hu, Xuexiang ; Qu, Jiuhui |
| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2009-04-15 |
| 卷号 | 43期号:8页码:2760-2765 |
| 中文摘要 | The photodegradation of the widely used amine drugs including primary amine (mexiletine), secondary amine (propranolol, phenytoin), and tertiary amine (diphenhydramine, antipyrine) were investigated in the presence of nitrate and humic substances under simulated sunlight. All of the amine drugs were photodegraded by nitrate due to the attack of hydroxyl radicals ((center dot)OH). The bimolecular rate constants for the reaction between each amine drug and (center dot)OH ranged from (2.1 +/- 0.2) x 10(9) to (8.7 +/- 0.3) x 10(9) M(-1) s(-1). In contrast only mexiletine, propranolol, and diphenhydramine were selectively photodegraded in the presence of humic substances (HS). Fulvic acid was a more efficient sensitizer than humic acid throughout. The HS triplet states were verified to be main reactive species in the photochemical reaction. Furthermore, an electron transfer mechanism for the reaction with the HS triplet states was proposed on the basis of all information, obtained under a series of experiments. The electron transfer from the nonbonding electrons on nitrogen (N-electrons) of the amine drugs to the excited ketone of the HS occurred. The availability of N-electrons and presence of hydrogen on carbon alpha of amine (alpha-hydrogen) were two key factors for the electron-transfer interaction. Moreover, the photoproducts were identified by GC-MS and the degradation pathways were proposed. The results strongly suggest the impact of humic substances on the photochemical fate of amine drugs in the natural waters. |
| WOS记录号 | WOS:000265172800018 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/21691]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen, Yong,Hu, Chun,Hu, Xuexiang,et al. Indirect Photodegradation of Amine Drugs in Aqueous Solution under Simulated Sunlight[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2009,43(8):2760-2765. |
| APA | Chen, Yong,Hu, Chun,Hu, Xuexiang,&Qu, Jiuhui.(2009).Indirect Photodegradation of Amine Drugs in Aqueous Solution under Simulated Sunlight.ENVIRONMENTAL SCIENCE & TECHNOLOGY,43(8),2760-2765. |
| MLA | Chen, Yong,et al."Indirect Photodegradation of Amine Drugs in Aqueous Solution under Simulated Sunlight".ENVIRONMENTAL SCIENCE & TECHNOLOGY 43.8(2009):2760-2765. |
入库方式： OAI收割
来源：生态环境研究中心
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