In vitro profiling of the endocrine disrupting potency of organochlorine pesticides
文献类型：期刊论文
| 作者 | Li, Jian ; Li, Na ; Ma, Mei ; Giesy, John P. ; Wang, Zijian |
| 刊名 | TOXICOLOGY LETTERS
 |
| 出版日期 | 2008-12-15 |
| 卷号 | 183期号:2015-01-03页码:65-71 |
| 关键词 | Organochlorine pesticides Estrogen receptor Androgen receptor Progesterone receptor Estrogen-related receptor Endocrine disruptor |
| 英文摘要 | Some organochlorine pesticides (OCPs) are suspected of modulating the endocrine systems of humans. Aspects of neuro-endocrine system modulation include interactions such as agonism or antagonism of estrogen receptor (ER) binding. However, less is known about their interactions with other nuclear receptors (NRs). The objectives of this study were to determine and compare the ability of p,p'-dichlorodiphenylethane (p,p'-DDE), p,p'-diclilorodiPhenyltrichloroethane (p,p'-DDT), hexachlorobenzene (HCB) and r-hexachlorocyclohexane (r-HCH) to interact with ER alpha, androgen receptor (AR), progesterone receptor (PR) and estrogen-related receptor (ERR gamma) using a set of recombined yeast strains expressing beta-galactosidase, under control of ERa, AR, PR or ERR gamma. The results showed that p,p'-DDE was an ER alpha agonist, AR and PR antagonist (PR > AR), while p,p'-DDT was an ER alpha agonist and AR antagonist. HCB and r-HCH were antagonists for AR and ERR gamma, while r-HCH was a PR antagonist and a weak antagonist of ERR gamma, and was able to reverse the ERR gamma inhibition induced by 4-hydroxytamoxifen. All the results suggested that, for the tested OCPs, their ability to act as endocrine disruptors involves more than one mechanism, their (anti-)agonistic effects on different receptors should not be overlooked, and the potential for additive or synergistic effects must be taken into consideration in the risk assessment process. (c) 2008 Elsevier Ireland Ltd. All rights reserved. |
| WOS记录号 | WOS:000262053000009 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/22250]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, Jian,Li, Na,Ma, Mei,et al. In vitro profiling of the endocrine disrupting potency of organochlorine pesticides[J]. TOXICOLOGY LETTERS,2008,183(2015-01-03):65-71. |
| APA | Li, Jian,Li, Na,Ma, Mei,Giesy, John P.,&Wang, Zijian.(2008).In vitro profiling of the endocrine disrupting potency of organochlorine pesticides.TOXICOLOGY LETTERS,183(2015-01-03),65-71. |
| MLA | Li, Jian,et al."In vitro profiling of the endocrine disrupting potency of organochlorine pesticides".TOXICOLOGY LETTERS 183.2015-01-03(2008):65-71. |
入库方式： OAI收割
来源：生态环境研究中心
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