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Abnormal Diffusion of Cerebral White Matter in Early Blindness

文献类型：期刊论文

作者Shu, Ni1; Li, Jun1; Li, Kuncheng2; Yu, Chunshui2; Jiang, Tianzi1
刊名HUMAN BRAIN MAPPING
出版日期2009
卷号30期号:1页码:220-227
关键词early blind diffusion tensor imaging tractography visual system
英文摘要Early visual deprivation may lead to both abnormal and plastic changes in the visual and other systems of the brain. Such secondary changes in the gray matter of the early blind have been well studied, but not so well in the cerebral white matter whose subtle changes may be revealed by diffusion tensor imaging. The first purpose of this study is to explore the possible changed white matter regions of the early blind in whole brain manners, using voxel-based analysis (VBA) and tract-based spatial statistics (TBSS) methods. The second purpose is to investigate the changes of diffusion eigenvalues in the abnormal white matter fiber tracts using tractography based group mapping analysis. From VBA of fractional anisotropy (FA) images, the significant changed white matter regions were the geniculocalcarine tract (GCT) and its adjacent regions. This finding was validated by TBSS method. Then we studied the changes of mean diffusivity (MD), FA, primary (lambda(1)) and transverse diffusivities (lambda(23)) in the GCT using tractography based group mapping analysis. We found the early blind had significantly lower FA (P < 0.0001), higher MD (P = 0.001) and lambda(23) (P < 0.0001) in the GCT. This pattern of diffusion changes is similar to findings seen in immaturity or axonal degeneration. Thus, we suggest that transneuronal degeneration and/or immaturity may account for the abnormal diffusion changes in the GCT of the early blind. Ham Brain Mapp 30:220-227, 2009. (c) 2007 Wiley-Liss, Inc.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]RELAPSING NEUROMYELITIS-OPTICA ; VISUAL-CORTEX ACTIVATION ; FRACTIONAL ANISOTROPY ; QUANTITATIVE-ANALYSIS ; TENSOR TRACTOGRAPHY ; BRAIN ; SCHIZOPHRENIA ; HUMANS ; TRACT ; FMRI
收录类别SCI
语种英语
WOS记录号WOS:000262397000019
源URL[http://ir.ia.ac.cn/handle/173211/3098]  
专题自动化研究所_脑网络组研究中心
作者单位1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China
2.Xuanwu Hosp Capital Med Univ, Dept Radiol, Beijing 100053, Peoples R China
推荐引用方式
GB/T 7714		 Shu, Ni,Li, Jun,Li, Kuncheng,et al. Abnormal Diffusion of Cerebral White Matter in Early Blindness[J]. HUMAN BRAIN MAPPING,2009,30(1):220-227.
APA Shu, Ni,Li, Jun,Li, Kuncheng,Yu, Chunshui,&Jiang, Tianzi.(2009).Abnormal Diffusion of Cerebral White Matter in Early Blindness.HUMAN BRAIN MAPPING,30(1),220-227.
MLA Shu, Ni,et al."Abnormal Diffusion of Cerebral White Matter in Early Blindness".HUMAN BRAIN MAPPING 30.1(2009):220-227.

入库方式： OAI收割

来源：自动化研究所

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