Cerebellum Abnormalities in Idiopathic Generalized Epilepsy with Generalized Tonic-Clonic Seizures Revealed by Diffusion Tensor Imaging
文献类型：期刊论文
| 作者 | Li, Yonghui1,2; Du, Hanjian; Xie, Bing4; Wu, Nan3; Wang, Jian4; Wu, Guocai3; Feng, Hua3; Jiang, Tianzi2,5
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| 刊名 | PLOS ONE
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| 出版日期 | 2010-12-21 |
| 卷号 | 5期号:12 |
| 英文摘要 | Although there is increasing evidence suggesting that there may be subtle abnormalities in idiopathic generalized epilepsy (IGE) patients using modern neuroimaging techniques, most of these previous studies focused on the brain grey matter, leaving the underlying white matter abnormalities in IGE largely unknown, which baffles the treatment as well as the understanding of IGE. In this work, we adopted multiple methods from different levels based on diffusion tensor imaging (DTI) to analyze the white matter abnormalities in 14 young male IGE patients with generalized tonic-clonic seizures (GTCS) only, comparing with 29 age-matched male healthy controls. First, we performed a voxel-based analysis (VBA) of the fractional anisotropy (FA) images derived from DTI. Second, we used a tract-based spatial statistics (TBSS) method to explore the alterations within the white matter skeleton of the patients. Third, we adopted region-of-interest (ROI) analyses based on the findings of VBA and TBSS to further confirm abnormal brain regions in the patients. At last, considering the convergent evidences we found by VBA, TBSS and ROI analyses, a subsequent probabilistic fiber tractography study was performed to investigate the abnormal white matter connectivity in the patients. Significantly decreased FA values were consistently observed in the cerebellum of patients, providing fresh evidence and new clues for the important role of cerebellum in IGE with GTCS. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | DT-MRI DATA ; HUMAN THALAMUS ; WHITE-MATTER ; HUMAN BRAIN ; TRACTOGRAPHY ; CONNECTIVITY ; CORTEX ; GANGLIOGLIOMA ; STIMULATION ; PATTERNS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000285576900023 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3108]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Chinese Acad Sci, Natl Res Ctr Intelligent Comp Syst, Inst Comp Technol, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing, Peoples R China 3.Third Mil Med Univ, Southwest Hosp, Dept Neurosurg, Chongqing, Peoples R China 4.Third Mil Med Univ, Southwest Hosp, Dept Radiol, Chongqing, Peoples R China 5.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yonghui,Du, Hanjian,Xie, Bing,et al. Cerebellum Abnormalities in Idiopathic Generalized Epilepsy with Generalized Tonic-Clonic Seizures Revealed by Diffusion Tensor Imaging[J]. PLOS ONE,2010,5(12). |
| APA | Li, Yonghui.,Du, Hanjian.,Xie, Bing.,Wu, Nan.,Wang, Jian.,...&Jiang, Tianzi.(2010).Cerebellum Abnormalities in Idiopathic Generalized Epilepsy with Generalized Tonic-Clonic Seizures Revealed by Diffusion Tensor Imaging.PLOS ONE,5(12). |
| MLA | Li, Yonghui,et al."Cerebellum Abnormalities in Idiopathic Generalized Epilepsy with Generalized Tonic-Clonic Seizures Revealed by Diffusion Tensor Imaging".PLOS ONE 5.12(2010). |
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