COMT Val158Met Modulates Association Between Brain White Matter Architecture and IQ
文献类型：期刊论文
| 作者 | Li, Jun1,3; Yu, Chunshui2; Li, Yonghui1; Liu, Bing1 ; Liu, Yong1; Shu, Ni1; Song, Ming1; Zhou, Yuan1; Zhu, Wanlin1; Li, Kuncheng2
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| 刊名 | AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
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| 出版日期 | 2009-04-05 |
| 卷号 | 150B期号:3页码:375-380 |
| 关键词 | catechol-o-methyltransferase dopamine intelligence diffusion tensor imaging white matter |
| 英文摘要 | The intelligence quotient (IQ) is typically associated with the architecture of gray and white matter in specific brain regions, and this association appears to be genetically based. However, specific sources of genetic variation for the association have not been studied extensively. Using diffusion tensor imaging in 15 mental retardation patients and 80 healthy volunteers, we studied the association between white matter architecture and IQ and also investigated the effects of COMT val158met on this association. The results showed that fractional anisotropy (FA) values in the prefrontal lobe and the hippocampus formation were associated with IQ and that val158met may affect this association. Subjects who were val homozygous showed steeper slopes for regression of the FA value on IQ than met carriers. Our findings suggest that COMT val158met may contribute to intelligence by affecting the association between IQ and the white matter architecture in the prefrontal lobe and the hippocampal formation. (C) 2008 Wiley-Liss, Inc. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Genetics & Heredity ; Psychiatry |
| 研究领域[WOS] | Genetics & Heredity ; Psychiatry |
| 关键词[WOS] | CATECHOL-O-METHYLTRANSFERASE ; 22Q11.2 DELETION SYNDROME ; HEALTHY-ADULTS ; PREFRONTAL CORTEX ; INTELLECTUAL ABILITY ; FLUID INTELLIGENCE ; CHILDREN ; POLYMORPHISM ; MYELINATION ; ADOLESCENTS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000264675500009 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3109]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 2.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China 3.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jun,Yu, Chunshui,Li, Yonghui,et al. COMT Val158Met Modulates Association Between Brain White Matter Architecture and IQ[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2009,150B(3):375-380. |
| APA | Li, Jun.,Yu, Chunshui.,Li, Yonghui.,Liu, Bing.,Liu, Yong.,...&Jiangi, Tianzi.(2009).COMT Val158Met Modulates Association Between Brain White Matter Architecture and IQ.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,150B(3),375-380. |
| MLA | Li, Jun,et al."COMT Val158Met Modulates Association Between Brain White Matter Architecture and IQ".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 150B.3(2009):375-380. |
入库方式： OAI收割
来源：自动化研究所
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