Cortical thickness is associated with different apolipoprotein E genotypes in healthy elderly adults
文献类型：期刊论文
| 作者 | Fan, Ming1; Liu, Bing1 ; Zhou, Yuan1,2; Zhen, Xiantong3; Xu, Cunlu3; Jiang, Tianzi1; Alzheimers Dis Neuroimaging Initia
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| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2010-08-02 |
| 卷号 | 479期号:3页码:332-336 |
| 关键词 | Cortical thickness Apolipoprotein E Alzheimer's disease |
| 英文摘要 | Previous studies have consistently suggested that the epsilon 4 allele of apolipoprotein E (APOE) gene is a major risk factor for Alzheimer's disease (AD). However, whether the epsilon 2 allele, a possible protective factor for AD, will express its protective effect in terms of cortical thickness in healthy elderly carriers is unclear. The goal of this study is to clarify the effects of APOE genotypes on cortical thickness in nondemented elderly subjects. We used 164 healthy, cognitively normal, elderly subjects, who were grouped into epsilon 2 carriers, epsilon 3 homozygotes, and epsilon 4 carriers respectively. The APOE epsilon 2 carriers had a significant thicker (corrected p < 0.05)cortical thickness in the superior temporal cortex compared with the epsilon 3 homozygotes. In addition to this area, the APOE epsilon 2 carriers had a significantly thicker region in the dorsolateral prefrontal cortex (corrected p < 0.05) than did the epsilon 4 carriers. These findings suggest that the different alleles of the APOE gene have distinct neuroanatomic effects in elderly healthy subjects and may play specific roles in the development of AD. (C) 2010 Elsevier Ireland Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | EARLY ALZHEIMERS-DISEASE ; SURFACE-BASED ANALYSIS ; APOE GENOTYPE ; COORDINATE SYSTEM ; HIPPOCAMPAL ; BIOMARKERS ; AGE ; CARRIERS ; ALLELE ; CORTEX |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000280100600032 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3110]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Chinese Acad Sci, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Ctr Social & Econ Behav, Inst Psychol, Beijing 100101, Peoples R China 3.Lanzhou Univ, Sch Informat Sci & Engn, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Ming,Liu, Bing,Zhou, Yuan,et al. Cortical thickness is associated with different apolipoprotein E genotypes in healthy elderly adults[J]. NEUROSCIENCE LETTERS,2010,479(3):332-336. |
| APA | Fan, Ming.,Liu, Bing.,Zhou, Yuan.,Zhen, Xiantong.,Xu, Cunlu.,...&Alzheimers Dis Neuroimaging Initia.(2010).Cortical thickness is associated with different apolipoprotein E genotypes in healthy elderly adults.NEUROSCIENCE LETTERS,479(3),332-336. |
| MLA | Fan, Ming,et al."Cortical thickness is associated with different apolipoprotein E genotypes in healthy elderly adults".NEUROSCIENCE LETTERS 479.3(2010):332-336. |
入库方式： OAI收割
来源：自动化研究所
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