Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease
文献类型：期刊论文
| 作者 | Xu, Cunlu1,2; Wang, Zhenhua1,2; Fan, Ming1; Liu, Bing1 ; Song, Ming1; Zhen, Xiantong2; Jiang, Tianzi1; Alzheimers Dis Neuroimaging Initia
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| 刊名 | NEUROREPORT
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| 出版日期 | 2010-08-23 |
| 卷号 | 21期号:12页码:802-807 |
| 关键词 | Alzheimer's disease brain-derived neurotrophic factor cerebral metabolic rate for glucose polymorphism positron emission tomography |
| 英文摘要 | Earlier studies showed that the Val66Met polymorphisms of the brain-derived neurotrophic factor differentially affect gray matter volume and brain region activities. This study used resting positron emission tomography to investigate the relationship between the polymorphisms of Val66Met and the regional cerebral metabolic rate in the brain. We analyzed the positron emission tomography images of 215 patients from the Alzheimer's Disease Neuroimaging Initiative and found significant differences in the parahippocampal gyrus, superior temporal gyrus, prefrontal cortex, and inferior parietal lobule when comparing Met carriers with noncarriers among both the normal controls and those with mild cognitive impairment. For those with Alzheimer's disease, we also found additional differences in the bilateral insula between the carriers and noncarriers. NeuroReport 21:802-807 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | NEUROTROPHIC FACTOR ; HIPPOCAMPAL ACTIVITY ; DEMENTIA ; INSULA ; VOLUME ; GENE ; MRI ; AGE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000280592900002 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3116]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Chinese Acad Sci, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China 2.Lanzhou Univ, Sch Informat Sci & Engn, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Cunlu,Wang, Zhenhua,Fan, Ming,et al. Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease[J]. NEUROREPORT,2010,21(12):802-807. |
| APA | Xu, Cunlu.,Wang, Zhenhua.,Fan, Ming.,Liu, Bing.,Song, Ming.,...&Alzheimers Dis Neuroimaging Initia.(2010).Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease.NEUROREPORT,21(12),802-807. |
| MLA | Xu, Cunlu,et al."Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease".NEUROREPORT 21.12(2010):802-807. |
入库方式： OAI收割
来源：自动化研究所
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