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Recombination rates of human microRNA

文献类型：期刊论文

作者Zhao, Huizhi1,2,3; Wang, Dong3,4; Liu, Bing1,2; Jiang, Xingpeng1,2; Zhang, Jing1,2; Fan, Ming1,2; Fan, Zhengjie1,2; Chen, Ying1,2; Song, Sonya Wei1,2; Gao, Wei3,4
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
出版日期2009-02-13
卷号379期号:3页码:702-705
关键词MicroRNAs Recombination rate Tissue specificity Disease MicroRNA expression level
英文摘要The fact that microRNAs play a role in almost all biological processes is well established, as is the importance of recombination in generating genome variability. However, the association between microRNAs and recombination remains largely unknown. In order to investigate the recombination patterns of microRNAs, we performed a comprehensive analysis of the recombination rate of human microRNAs. We observed that microRNAs that are expressed in several tissues tend to have lower recombination rates than tissue-specific microRNAs. Additionally, microRNAs that are associated with a number of diseases are also likely to have lower recombination rates. Furthermore, microRNAs with higher expression levels are found to have fewer recombination events. These findings reveal patterns in recombination rates of microRNAs that could help ill understanding the function, evolution, and disease-related roles of microRNAs. (C) 2008 Elsevier Inc. All rights reserved.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]HUMAN GENOME ; GENETIC ROBUSTNESS ; HUMAN TISSUES ; GC CONTENT ; EXPRESSION ; EVOLUTION ; PROFILES ; CANCER ; BIAS
收录类别SCI
语种英语
WOS记录号WOS:000263258100011
源URL[http://ir.ia.ac.cn/handle/173211/3132]  
专题自动化研究所_脑网络组研究中心
作者单位1.Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Med Informat, Beijing 100083, Peoples R China
4.Peking Univ, MOE Key Lab Mol Cardiol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Huizhi,Wang, Dong,Liu, Bing,et al. Recombination rates of human microRNA[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,379(3):702-705.
APA Zhao, Huizhi.,Wang, Dong.,Liu, Bing.,Jiang, Xingpeng.,Zhang, Jing.,...&Cui, Qinghua.(2009).Recombination rates of human microRNA.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,379(3),702-705.
MLA Zhao, Huizhi,et al."Recombination rates of human microRNA".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 379.3(2009):702-705.

入库方式： OAI收割

来源：自动化研究所

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