Reduced prefrontal activation during Tower of London in first-episode schizophrenia: A multi-channel near-infrared spectroscopy study
文献类型：期刊论文
| 作者 | Zhu, Ye2; Liu, Xuan1 ; Wang, Huiling1; Jiang, Tianzi2; Fang, Yue1; Hu, Hanbin2; Wang, Gaohua1; Wang, Xiaoping1; Liu, Zhongchun1; Zhang, Kai1
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| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2010-07-12 |
| 卷号 | 478期号:3页码:136-140 |
| 关键词 | Schizophrenia Multi-channel near-infrared spectroscopy (NIRS) Tower of London (TOL) Prefrontal cortex (PFC) |
| 英文摘要 | Cognitive impairments are considered as a core feature of schizophrenia and have been reported in associated with dysfunction of the prefrontal cortex (PFC). The Tower of London (TOL) task is a widely used neuropsychological test to assess the planning ability and the PFC function. In the present study. we examined functional changes in the PFC of 40 first-episode schizophrenia patients and 40 age- and gender-matched healthy controls by means of multi-channel Near-infrared spectroscopy (MRS) during performance of the TOL task. NIRS is a noninvasive optical method that can measure relative changes in oxygenated ([oxy-Hb]) and deoxygenated ([deoxy-Hb]) hemoglobin in cortical tissue. Compared to the healthy controls, schizophrenia patients exhibited a significant decreased activation in the left PFC and poorer TOL performance. The results confirm the functional deficits of the PFC and impaired planning ability in first-episode schizophrenia patients and suggest that NIRS may be a useful clinical tool for evaluating PFC activation in psychiatric disorders. (c) 2010 Elsevier Ireland Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | DYSFUNCTION ; TASK |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000279525700006 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3134]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan 430060, Peoples R China 2.Chinese Acad Sci, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Ye,Liu, Xuan,Wang, Huiling,et al. Reduced prefrontal activation during Tower of London in first-episode schizophrenia: A multi-channel near-infrared spectroscopy study[J]. NEUROSCIENCE LETTERS,2010,478(3):136-140. |
| APA | Zhu, Ye.,Liu, Xuan.,Wang, Huiling.,Jiang, Tianzi.,Fang, Yue.,...&Zhang, Kai.(2010).Reduced prefrontal activation during Tower of London in first-episode schizophrenia: A multi-channel near-infrared spectroscopy study.NEUROSCIENCE LETTERS,478(3),136-140. |
| MLA | Zhu, Ye,et al."Reduced prefrontal activation during Tower of London in first-episode schizophrenia: A multi-channel near-infrared spectroscopy study".NEUROSCIENCE LETTERS 478.3(2010):136-140. |
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