Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex
文献类型：期刊论文
| 作者 | Hao, Yihui2; Yan, Qiang1; Liu, Haihong2; Xu, Lin2,3; Xue, Zhimin2; Song, Xueqin4; Kaneko, Yoshio5; Jiang, Tianzi6 ; Liu, Zhening2; Shan, Baoci1
|
| 刊名 | SCHIZOPHRENIA RESEARCH
 |
| 出版日期 | 2009-10-01 |
| 卷号 | 114期号:1-3页码:128-135 |
| 关键词 | Schizophrenia Healthy siblings Diffusion tensor imaging Fractional anisotropy |
| 英文摘要 | Healthy siblings of schizophrenia patients have an almost 9-fold higher risk for developing the illness than the general population. Disruption of white matter (WM) integrity as indicated by reduced fractional anisotropy (FA) derived from diffusion tensor imaging (DTI), is believed to be the key substrate of schizophrenia. However, it remains unclear whether schizophrenia patients and their healthy siblings share a specific pattern of disruption of WM integrity that may be related to the disease risk. The objective of this study is to determine whether a specific brain regional pattern of disruption of WM integrity is shared by schizophrenia patients and their healthy siblings. We investigated brain white matter abnormalities by voxel-based analysis of white matter FA data acquired from diffusion tensor imaging in 34 pairs of schizophrenia patients and their healthy siblings, as well as in 32 healthy controls. Both schizophrenia patients and their healthy siblings showed reduced white matter FA in the left prefrontal cortex and the hippocampus in comparison to healthy controls, without significant difference between patients and siblings. In marked contrast, only schizophrenia patients exhibited reduced white matter FA in the left anterior cingulate cortex in comparison to both siblings and controls, without significant difference between siblings and controls. Thus, schizophrenia patients and their healthy siblings share disruption of WM integrity in the left prefrontal cortex and the hippocampus that may be related to higher risk of healthy siblings to develop schizophrenia, which may be eventually attributed to additional disruption of WM integrity in the left anterior cingulate cortex. (C) 2009 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Psychiatry |
| 研究领域[WOS] | Psychiatry |
| 关键词[WOS] | 1ST-EPISODE SCHIZOPHRENIA ; 1ST-DEGREE RELATIVES ; COGNITIVE CONTROL ; GENETIC RISK ; STROOP TASK ; DIFFUSION ; BRAIN ; MRI ; ABNORMALITIES ; CONNECTIVITY |
| 收录类别 | SCI ; SSCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000270758700018 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3137]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Anal, Beijing 100049, Peoples R China 2.Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming, Peoples R China 4.Zhengzhou Univ, Affiliated Hosp 1, Dept Psychiat, Zhengzhou, Peoples R China 5.Yale Univ, Sch Med, New Haven, CT USA 6.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hao, Yihui,Yan, Qiang,Liu, Haihong,et al. Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex[J]. SCHIZOPHRENIA RESEARCH,2009,114(1-3):128-135. |
| APA | Hao, Yihui.,Yan, Qiang.,Liu, Haihong.,Xu, Lin.,Xue, Zhimin.,...&Shan, Baoci.(2009).Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex.SCHIZOPHRENIA RESEARCH,114(1-3),128-135. |
| MLA | Hao, Yihui,et al."Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex".SCHIZOPHRENIA RESEARCH 114.1-3(2009):128-135. |
入库方式： OAI收割
来源：自动化研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。