Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders
文献类型：期刊论文
| 作者 | Zhou, Yuan1,2 ; Wang, Kun1; Liu, Yong1; Song, Ming1; Song, Sonya W.1; Jiang, Tianzi1,3
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| 刊名 | COGNITIVE NEURODYNAMICS
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| 出版日期 | 2010 |
| 卷号 | 4期号:4页码:275-294 |
| 关键词 | Resting-state fMRI Low frequency fluctuation Functional connectivity Alzheimer's disease Schizophrenia |
| 英文摘要 | As functional magnetic resonance imaging (fMRI) studies have yielded increasing amounts of information about the brain's spontaneous activity, they have revealed fMRI's potential to locate changes in brain hemodynamics that are associated with neuropsychiatric disorders. In this paper, we review studies that support the notion that changes in brain spontaneous activity observed by fMRI can be used as potential biomarkers for diagnosis and treatment evaluation in neuropsychiatric disorders. We first review the methods used to study spontaneous activity from the perspectives of (1) the properties of local spontaneous activity, (2) the spatial pattern of spontaneous activity, and (3) the topological properties of brain networks. We also summarize the major findings associated with major neuropsychiatric disorders obtained using these methods. Then we review the pilot studies that have used spontaneous activity to discriminate patients from normal controls. Finally, we discuss current challenges and potential research directions to further elucidate the clinical use of spontaneous brain activity in neuropsychiatric disorders. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | RESTING-STATE FMRI ; INDEPENDENT COMPONENT ANALYSIS ; SMALL-WORLD NETWORKS ; LOW-FREQUENCY FLUCTUATIONS ; MILD COGNITIVE IMPAIRMENT ; BOLD SIGNAL FLUCTUATIONS ; ALZHEIMERS-DISEASE ; DEFAULT-MODE ; CEREBRAL-CORTEX ; ANATOMICAL CONNECTIVITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000284241800002 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3139]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Ctr Social & Econ Behav, Beijing 100101, Peoples R China 3.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Yuan,Wang, Kun,Liu, Yong,et al. Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders[J]. COGNITIVE NEURODYNAMICS,2010,4(4):275-294. |
| APA | Zhou, Yuan,Wang, Kun,Liu, Yong,Song, Ming,Song, Sonya W.,&Jiang, Tianzi.(2010).Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders.COGNITIVE NEURODYNAMICS,4(4),275-294. |
| MLA | Zhou, Yuan,et al."Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders".COGNITIVE NEURODYNAMICS 4.4(2010):275-294. |
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来源：自动化研究所
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