Temporal scaling properties and spatial synchronization of spontaneous blood oxygenation level-dependent (BOLD) signal fluctuations in rat sensorimotor network at different levels of isoflurane anesthesia
文献类型：期刊论文
| 作者 | Wang, Kun2; van Meer, Maurits P. A.1; van der Marel, Kajo1; van der Toorn, Annette1; Xu, Lijuan2; Liu, Yingjun2; Viergever, Max A.1; Jiang, Tianzi2 ; Dijkhuizen, Rick M.1
|
| 刊名 | NMR IN BIOMEDICINE
 |
| 出版日期 | 2011 |
| 卷号 | 24期号:1页码:61-67 |
| 关键词 | BOLD signal resting state functional MRI isoflurane anesthesia rat brain functional connectivity |
| 英文摘要 | Spontaneous fluctuations in the blood oxygenation level-dependent (BOLD) MRI signal during the resting state are increasingly being studied in healthy and diseased brain in humans and animal models. Yet, the relationship between functional brain status and the characteristics of spontaneous BOLD fluctuations remains poorly understood. In order to obtain more insights into this relationship and, in particular, the effects of anesthesia thereupon, we investigated the spatial and temporal correlations of spontaneous BOLD fluctuations in somatosensory and motor regions of rat brain at different inhalation levels of the frequently applied anesthetic isoflurane. We found that the temporal scaling, characterized by the Hurst exponent (H), showed persistent behavior (H > 0.5) at 0.5-1.0% isoflurane. Furthermore, low-pass-filtered spontaneous BOLD oscillations were correlated significantly in bilateral somatosensory and bilateral motor cortices, reflective of interhemispheric functional connectivity. Under 2.9% isoflurane anesthesia, the temporal scaling characteristics approached those of Gaussian white noise (H = 0.5), the relative amplitude of BOLD low-frequency fluctuations declined, and cross-correlations of these oscillations between functionally connected regions decreased significantly. Loss of interhemispheric functional connectivity at 2.9% isoflurane anesthesia was stronger between bilateral motor regions than between bilateral somatosensory regions, which points to distinct effects of anesthesia on differentially organized neuronal networks. Although we cannot completely rule out a possible contribution from hemodynamic signals with a non-neuronal origin, our results emphasize that spatiotemporal characteristics of spontaneous BOLD fluctuations are related to the brain's specific functional status and network organization, and demonstrate that these are largely preserved under light to mild anesthesia with isoflurane. Copyright (C) 2010 John Wiley & Sons, Ltd. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Technology |
| 类目[WOS] | Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy |
| 研究领域[WOS] | Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy |
| 关键词[WOS] | FUNCTIONAL CONNECTIVITY ; HUMAN BRAIN ; SEVOFLURANE ANESTHESIA ; GLUCOSE-UTILIZATION ; FMRI ; MRI ; ARCHITECTURE ; HALOTHANE ; DYNAMICS ; WAVELETS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000287110300007 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3140]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Univ Med Ctr Utrecht, Image Sci Inst, Biomed MR Imaging & Spect Grp, NL-3508 GA Utrecht, Netherlands 2.Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Kun,van Meer, Maurits P. A.,van der Marel, Kajo,et al. Temporal scaling properties and spatial synchronization of spontaneous blood oxygenation level-dependent (BOLD) signal fluctuations in rat sensorimotor network at different levels of isoflurane anesthesia[J]. NMR IN BIOMEDICINE,2011,24(1):61-67. |
| APA | Wang, Kun.,van Meer, Maurits P. A..,van der Marel, Kajo.,van der Toorn, Annette.,Xu, Lijuan.,...&Dijkhuizen, Rick M..(2011).Temporal scaling properties and spatial synchronization of spontaneous blood oxygenation level-dependent (BOLD) signal fluctuations in rat sensorimotor network at different levels of isoflurane anesthesia.NMR IN BIOMEDICINE,24(1),61-67. |
| MLA | Wang, Kun,et al."Temporal scaling properties and spatial synchronization of spontaneous blood oxygenation level-dependent (BOLD) signal fluctuations in rat sensorimotor network at different levels of isoflurane anesthesia".NMR IN BIOMEDICINE 24.1(2011):61-67. |
入库方式： OAI收割
来源：自动化研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。