Thick Visual Cortex in the Early Blind
文献类型：期刊论文
| 作者 | Jiang, Jiefeng1; Zhu, Wanlin1,2; Shi, Feng1; Liu, Yong1 ; Li, Jun1; Qin, Wen3; Li, Kuncheng3; Yu, Chunshui3; Jiang, Tianzi1
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| 刊名 | JOURNAL OF NEUROSCIENCE
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| 出版日期 | 2009-02-18 |
| 卷号 | 29期号:7页码:2205-2211 |
| 关键词 | cortical thickness blind plasticity visual deprivation magnetic resonance imaging development |
| 英文摘要 | We investigated the key neurodevelopmental factors that determine cortical thickness, namely synaptogenesis and regression, by analyzing the thickness of the visual cortex in humans with early- and late-onset blindness. The bilateral visual cortices of the early blind were significantly thicker than those of the late blind and the sighted controls, but the latter two groups did not differ significantly. This suggests reduced "pruning" of synapses in the visual cortex, which may be due to a lack of visual experience during a critical developmental period. These findings support the hypothesis that sensory experience is necessary for an appropriate regression and remodeling of neuronal processes and that synaptic regression might be a major determinant of macroscopic anatomical features like cortical thickness. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | CROSS-MODAL PLASTICITY ; CORTICAL THICKNESS ; RETINAL INPUT ; WHITE-MATTER ; POSTNATAL-DEVELOPMENT ; CONGENITALLY BLIND ; HUMAN BRAIN ; DEPRIVATION ; CONNECTIVITY ; ORGANIZATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000263558900024 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3141]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China 2.Zhejiang Univ, Dept Math, Hangzhou 310027, Peoples R China 3.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Jiefeng,Zhu, Wanlin,Shi, Feng,et al. Thick Visual Cortex in the Early Blind[J]. JOURNAL OF NEUROSCIENCE,2009,29(7):2205-2211. |
| APA | Jiang, Jiefeng.,Zhu, Wanlin.,Shi, Feng.,Liu, Yong.,Li, Jun.,...&Jiang, Tianzi.(2009).Thick Visual Cortex in the Early Blind.JOURNAL OF NEUROSCIENCE,29(7),2205-2211. |
| MLA | Jiang, Jiefeng,et al."Thick Visual Cortex in the Early Blind".JOURNAL OF NEUROSCIENCE 29.7(2009):2205-2211. |
入库方式： OAI收割
来源：自动化研究所
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