Less Efficient Information Transfer in Cys-Allele Carriers of DISC1: A Brain Network Study Based on Diffusion MRI
文献类型：期刊论文
| 作者 | Li, Yonghui1,2; Liu, Bing1 ; Hou, Bing1; Qin, Wen3; Wang, Dawei3; Yu, Chunshui3; Jiang, Tianzi1,2,4
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| 刊名 | CEREBRAL CORTEX
 |
| 出版日期 | 2013-07-01 |
| 卷号 | 23期号:7页码:1715-1723 |
| 关键词 | fiber tractography gene neuroimaging schizophrenia white matter |
| 英文摘要 | Previous neuroimaging studies of brain networks have revealed less efficient information transfer in patients with schizophrenia. However, the underlying genetic basis remains largely unexplored. In this study, we investigated the brain anatomical networks of 278 healthy volunteers with different genotypes in the common missense variant (Ser704Cys) of the Disrupted-in-Schizophrenia-1 (DISC1) gene, which is one of the main susceptibility genes of schizophrenia and other psychiatric disorders. The anatomical brain network for each individual was constructed using fiber tractography technique based on diffusion magnetic resonance imaging (dMRI). The properties of this network were then calculated using graph theory. This revealed that Cys-allele carriers showed significantly lower global efficiency of their brain networks than Ser homozygotes, thereby supporting our hypothesis that genetic variation in DISC1 may relate to the risk of schizophrenia by affecting the efficiency of brain network. Additional dMRI analyses were also performed at different levels, with a convergent trend towards decreased white matter integrity being consistently observed in Cys-allele carriers. Together these findings not only provide new clues for understanding DISC1 function, but also suggest that network analyses based on graph theory combined with neuroimaging techniques may reveal structural disruptions related to genetic risk in the brains of healthy individuals. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | SMALL-WORLD NETWORKS ; GRAPH-THEORETICAL ANALYSIS ; VOXEL-BASED MORPHOMETRY ; WHITE-MATTER ANATOMY ; COMPLEX NETWORKS ; IMAGING GENETICS ; HUMAN THALAMUS ; SCHIZOPHRENIA ; TRACTOGRAPHY ; ASSOCIATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000321163700021 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3145]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 2.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia 3.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 4.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yonghui,Liu, Bing,Hou, Bing,et al. Less Efficient Information Transfer in Cys-Allele Carriers of DISC1: A Brain Network Study Based on Diffusion MRI[J]. CEREBRAL CORTEX,2013,23(7):1715-1723. |
| APA | Li, Yonghui.,Liu, Bing.,Hou, Bing.,Qin, Wen.,Wang, Dawei.,...&Jiang, Tianzi.(2013).Less Efficient Information Transfer in Cys-Allele Carriers of DISC1: A Brain Network Study Based on Diffusion MRI.CEREBRAL CORTEX,23(7),1715-1723. |
| MLA | Li, Yonghui,et al."Less Efficient Information Transfer in Cys-Allele Carriers of DISC1: A Brain Network Study Based on Diffusion MRI".CEREBRAL CORTEX 23.7(2013):1715-1723. |
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来源：自动化研究所
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