Dosage Effects of BDNF Val66Met Polymorphism on Cortical Surface Area and Functional Connectivity
文献类型：期刊论文
| 作者 | Wang, Chao1 ; Zhang, Yuanchao1; Liu, Bing2,3; Long, Haixia2,3; Yu, Chunshui4; Jiang, Tianzi1,2,3,5
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| 刊名 | JOURNAL OF NEUROSCIENCE
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| 出版日期 | 2014-02-12 |
| 卷号 | 34期号:7页码:2645-2651 |
| 关键词 | anterior insula brain-derived neurotrophic factor (BDNF) functional connectivity surface area |
| 英文摘要 | The single nucleotide polymorphism (SNP) that leads to a valine-to-methionine substitution at codon 66 (Val66Met) in BDNF is correlated with differences in cognitive and memory functions, as well as with several neurological and psychiatric disorders. MRI studies have already shown that this genetic variant contributes to changes in cortical thickness and volume, but whether the Val66Met polymorphism affects the cortical surface area of healthy subjects remains unclear. Here, we used multimodal MRI to study whether this polymorphism would affect the cortical morphology and resting-state functional connectivity of a large sample of healthy Han Chinese human subjects. An SNP-wise general linear model analysis revealed a "dosage effect" of the Met allele, specifically a stepwise increase in cortical surface area of the right anterior insular cortex with increasing numbers of the Met allele. Moreover, we found enhanced functional connectivity between the anterior insular and the dorsolateral prefrontal cortices that was linked with the dosage of the Met allele. In conclusion, these data demonstrated a "dosage effect" of BDNF Val66Met on normal cortical structure and function, suggesting a new path for exploring the mechanisms underlying the effects of genotype on cognition. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | ACTIVITY-DEPENDENT SECRETION ; HUMAN CEREBRAL-CORTEX ; NEUROTROPHIC FACTOR ; VAL(66)MET POLYMORPHISM ; MAJOR DEPRESSION ; HIPPOCAMPAL FUNCTION ; PREFRONTAL CORTEX ; MENTAL-DISORDERS ; MESSENGER-RNA ; HUMAN-MEMORY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000331614700025 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3150]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 4.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia |
| 推荐引用方式 GB/T 7714 | Wang, Chao,Zhang, Yuanchao,Liu, Bing,et al. Dosage Effects of BDNF Val66Met Polymorphism on Cortical Surface Area and Functional Connectivity[J]. JOURNAL OF NEUROSCIENCE,2014,34(7):2645-2651. |
| APA | Wang, Chao,Zhang, Yuanchao,Liu, Bing,Long, Haixia,Yu, Chunshui,&Jiang, Tianzi.(2014).Dosage Effects of BDNF Val66Met Polymorphism on Cortical Surface Area and Functional Connectivity.JOURNAL OF NEUROSCIENCE,34(7),2645-2651. |
| MLA | Wang, Chao,et al."Dosage Effects of BDNF Val66Met Polymorphism on Cortical Surface Area and Functional Connectivity".JOURNAL OF NEUROSCIENCE 34.7(2014):2645-2651. |
入库方式： OAI收割
来源：自动化研究所
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