Functional Connectivity in Healthy Subjects Is Nonlinearly Modulated by the COMT and DRD2 Polymorphisms in a Functional System-Dependent Manner
文献类型：期刊论文
| 作者 | Tian, Tian1; Qin, Wen1; Liu, Bing2,3 ; Jiang, Tianzi2,3,4,5; Yu, Chunshui1
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| 刊名 | JOURNAL OF NEUROSCIENCE
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| 出版日期 | 2013-10-30 |
| 卷号 | 33期号:44页码:17519-17526 |
| 英文摘要 | The dopamine system is known to modulate brain function in an inverted U-shaped manner. Recently, the functional networks of the brain were categorized into two systems, a "control system" and a "processing system." However, it remains unclear whether the inverted U-shaped model of dopaminergic modulation could be applied to both of these functional systems. The catechol-O-methyltransferase (COMT) and dopamine D-2 receptor (DRD2) were genotyped in 258 healthy young human subjects. The local and long-range functional connectivity densities (FCDs) of each voxel were calculated and compared in a voxel-wise manner using a two-way (COMT and DRD2 genotypes) analysis of covariance. The resting-state functional connectivity analysis was performed to determine the functional networks to which brain regions with significant FCD differences belonged. Significant COMT X DRD2 interaction effects were found in the local FCDs of the superior portion of the right temporal pole (sTP) and left lingual gyrus (LG) and in the long-range FCDs of the right putamen and left medial prefrontal cortex (MPFC). Post hoc tests showed nonlinear relationships between the genotypic subgroups and FCD. In the control system, the sTP and putamen, components of the salience network, showed a U-shaped modulation by dopamine signaling. In the processing system, however, the MPFC of the default-mode network and the LG of the visual network showed an inverted U-shaped modulation by the dopamine system. Our findings suggest an interaction between COMT and DRD2 genotypes and show a functional system-dependent modulation of dopamine signaling. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | O-METHYLTRANSFERASE COMT ; WORKING-MEMORY ; HUMAN BRAIN ; PREFRONTAL CORTEX ; DOPAMINE TRANSPORTER ; GENE-EXPRESSION ; RECEPTOR ; NETWORKS ; VAL(158)MET ; VAL158MET |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000326509800029 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3151]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 2.Chinese Acad Sci, Brainnetome Ctr, Beijing, Peoples R China 3.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R China 4.Univ Elect Sci & Technol China, Minist Educ, Sch Life Sci & Technol, Key Lab NeuroInformat, Chengdu 610054, Peoples R China 5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia |
| 推荐引用方式 GB/T 7714 | Tian, Tian,Qin, Wen,Liu, Bing,et al. Functional Connectivity in Healthy Subjects Is Nonlinearly Modulated by the COMT and DRD2 Polymorphisms in a Functional System-Dependent Manner[J]. JOURNAL OF NEUROSCIENCE,2013,33(44):17519-17526. |
| APA | Tian, Tian,Qin, Wen,Liu, Bing,Jiang, Tianzi,&Yu, Chunshui.(2013).Functional Connectivity in Healthy Subjects Is Nonlinearly Modulated by the COMT and DRD2 Polymorphisms in a Functional System-Dependent Manner.JOURNAL OF NEUROSCIENCE,33(44),17519-17526. |
| MLA | Tian, Tian,et al."Functional Connectivity in Healthy Subjects Is Nonlinearly Modulated by the COMT and DRD2 Polymorphisms in a Functional System-Dependent Manner".JOURNAL OF NEUROSCIENCE 33.44(2013):17519-17526. |
入库方式： OAI收割
来源：自动化研究所
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