Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects
文献类型：期刊论文
| 作者 | Wang, Junping1 ; Qin, Wen1; Liu, Bing2; Wang, Dawei1; Zhang, Yunting1; Jiang, Tianzi2; Yu, Chunshui1
|
| 刊名 | NEUROIMAGE
 |
| 出版日期 | 2013-11-01 |
| 卷号 | 81页码:199-204 |
| 关键词 | Oxytocin receptor Single nucleotide polymorphism Autism Hypothalamus Functional connectivity |
| 英文摘要 | The oxytocin receptor gene (OXTR) rs53576A has been associated with autism spectrum disorders (ASDs). A smaller hypothalamic volume has been reported in healthy male A-allele carriers than in male GG homozygotes and in patients with ASDs than in healthy controls. These findings prompt the hypothesis that male AA homozygotes may have weaker hypothalamic functional connectivity when compared to male G-allele carriers. We calculated local functional connectivity density (FCD) using a voxel-wise data-driven approach based on resting-state functional MRI data in 270 young healthy subjects. Both the main effect of genotype and the gender-by-genotype interaction were considered. Of the whole brain, only the local FCD of the hypothalamus exhibited the main effect of genotype. Post-hoc testing revealed significantly lower local FCD in male AA homozygotes compared to male G-allele carriers although there was only a trend of significance in the gender-by-genotype interaction. We further analyzed the resting-state functional connectivity (rsFC) of the hypothalamic region that demonstrating significant genotype differences in local FCD. We found a significant gender-by-genotype interaction in rsFC between the hypothalamic region and the left dorsolateral prefrontal cortex, but no significant main effect of genotype was found. Post-hoc testing revealed that this rsFC was significantly weaker in male AA homozygotes compared to male G-allele carriers. Our findings identify gender-dependent mechanisms of OXTR rs53576 gene variation impacting the functional connectivity of the hypothalamus in healthy individuals and suggest that these mechanisms are important for understanding ASDs. (C) 2013 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | AUTISM SPECTRUM DISORDERS ; OXYTOCIN RECEPTOR OXTR ; VASOPRESSIN ; MRI ; THERAPEUTICS ; ASSOCIATION ; POPULATION ; BEHAVIOR ; MATTER ; MEMORY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000322934400019 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3158]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Junping,Qin, Wen,Liu, Bing,et al. Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects[J]. NEUROIMAGE,2013,81:199-204. |
| APA | Wang, Junping.,Qin, Wen.,Liu, Bing.,Wang, Dawei.,Zhang, Yunting.,...&Yu, Chunshui.(2013).Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects.NEUROIMAGE,81,199-204. |
| MLA | Wang, Junping,et al."Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects".NEUROIMAGE 81(2013):199-204. |
入库方式： OAI收割
来源：自动化研究所
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