中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Brainnetome: A new -ome to understand the brain and its disorders

文献类型:期刊论文

作者Jiang, Tianzi1,2,3,4
刊名NEUROIMAGE
出版日期2013-10-15
卷号80页码:263-272
关键词Brainnetome Brain network Connectome Brain connectivity Neuroimaging
英文摘要The human brain can be studied as a hierarchy of complex networks on different temporal and spatial scales. On each scale, from gene, protein, synapse, neuron and microcircuit, to area, pathway and the whole brain, many advances have been made with the development of related techniques. Brain network studies on different temporal and spatial scales are booming. However, such studies have focused on single levels, and can only reflect limited aspects of how the brain is formed and how it works. Therefore, it is increasingly urgent to integrate a variety of techniques, methods and models, and to merge fragmented findings into a uniform research framework or platform. To this end, we have proposed the concept of the brainnetome and several related programs/projects have been launched in China. In this paper, we offer a brief review on the methodologies of the brainnetome, which include techniques on different scales, the brainnetome atlas, and methods of brain network analysis. We then take Alzheimer's disease and schizophrenia as examples to show how the brainnetome can be studied in neurological and psychiatric disorders. We also review the studies of how risk genes for brain diseases affect the brain networks. Finally, we summarize the challenges for the brainnetome, and what actions and measures have been taken to address these challenges in China. It is envisioned that the brainnetome will open new avenues and some long-standing issues may be solved by combining the brainnetome with other "omes". (C) 2013 Elsevier Inc. All rights reserved.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]RESTING-STATE FMRI ; SEROTONIN TRANSPORTER GENE ; MAJOR DEPRESSIVE DISORDER ; TRACTOGRAPHY-BASED PARCELLATION ; COGNITIVE IMPAIRMENT EVIDENCE ; EARLY ALZHEIMERS-DISEASE ; WHITE-MATTER INTEGRITY ; SMALL-WORLD NETWORKS ; FUNCTIONAL CONNECTIVITY ; ANTIDEPRESSANT RESPONSE
收录类别SCI
语种英语
WOS记录号WOS:000322416000020
源URL[http://ir.ia.ac.cn/handle/173211/3159]  
专题自动化研究所_脑网络组研究中心
作者单位1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
4.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
推荐引用方式
GB/T 7714
Jiang, Tianzi. Brainnetome: A new -ome to understand the brain and its disorders[J]. NEUROIMAGE,2013,80:263-272.
APA Jiang, Tianzi.(2013).Brainnetome: A new -ome to understand the brain and its disorders.NEUROIMAGE,80,263-272.
MLA Jiang, Tianzi."Brainnetome: A new -ome to understand the brain and its disorders".NEUROIMAGE 80(2013):263-272.

入库方式: OAI收割

来源:自动化研究所

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