Longitudinal changes in sulcal morphology associated with late-life aging and MCI
文献类型：期刊论文
| 作者 | Liu, Tao1; Sachdev, Perminder S.1,2; Lipnicki, Darren M.1; Jiang, Jiyang1; Cui, Yue1,3 ; Kochan, Nicole A.1,2; Reppermund, Simone1; Trollor, Julian N.1,4; Brodaty, Henry1,5,6; Wen, Wei1,2
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| 刊名 | NEUROIMAGE
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| 出版日期 | 2013-07-01 |
| 卷号 | 74页码:337-342 |
| 关键词 | Cortical sulci Magnetic resonance imaging Mild cognitive impairment Aging Sulcal width |
| 英文摘要 | The present study investigated changes in sulcal morphology associated with late-life aging and mild cognitive impairment (MCI). Participants were 219 community-dwelling 70-90 year-olds from the Sydney Memory and Ageing Study; all had MRI scans and were classified as having normal cognition (NC) or MCI at each of waves 1 and 2, two years apart. Automated methods were used to calculate a global sulcal index (g-SI), widths of five prominent sulci, and regional cortical thickness. There were significant longitudinal declines in g-SI and increases in sulcal width among the entire sample, but the rate of change differed among cognitive subgroups. Participants with MCI at both waves (persisting MCI) showed accelerated sulcal widening, particularly for the superior frontal and superior temporal sulci. The sulcal morphology of participants who reverted from MCI to NC was more consistent with stable NC than persisting MCI. Overall cortical thickness decreased between waves similarly across the subgroups. While changes in sulcal morphology are characteristic of normal late-life aging, they are accelerated in individuals with MCI (in contrast to changes in cortical thickness). Sulcal measures also differentiate between persistent MCI and MCI that reverts to NC, and may thus help in predicting the prognosis of MCI patients. Crown Copyright (c) 2013 Published by Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | MILD COGNITIVE IMPAIRMENT ; HUMAN CEREBRAL-CORTEX ; ALZHEIMERS-DISEASE ; CORTICAL THICKNESS ; BRAIN ; PATTERNS ; AGE ; VARIABILITY ; ATROPHY ; SYSTEM |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000317441300033 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3161]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Univ New S Wales, Sch Psychiat, Ctr Hlth Brain Ageing CHeBA, Sydney, NSW, Australia 2.Prince Wales Hosp, Inst Neuropsychiat, Randwick, NSW 2031, Australia 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing 100864, Peoples R China 4.Univ New S Wales, Sch Psychiat, Dept Dev Disabil Neuropsychiat, Sydney, NSW, Australia 5.Prince Wales Hosp, Aged Care Psychiat, Randwick, NSW 2031, Australia 6.Univ New S Wales, Dementia Collaborat Res Ctr, Sydney, NSW, Australia |
| 推荐引用方式 GB/T 7714 | Liu, Tao,Sachdev, Perminder S.,Lipnicki, Darren M.,et al. Longitudinal changes in sulcal morphology associated with late-life aging and MCI[J]. NEUROIMAGE,2013,74:337-342. |
| APA | Liu, Tao.,Sachdev, Perminder S..,Lipnicki, Darren M..,Jiang, Jiyang.,Cui, Yue.,...&Wen, Wei.(2013).Longitudinal changes in sulcal morphology associated with late-life aging and MCI.NEUROIMAGE,74,337-342. |
| MLA | Liu, Tao,et al."Longitudinal changes in sulcal morphology associated with late-life aging and MCI".NEUROIMAGE 74(2013):337-342. |
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来源：自动化研究所
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