Anatomical insights into disrupted small-world networks in schizophrenia
文献类型：期刊论文
| 作者 | Wang, Qifeng1; Su, Tung-Ping2,3; Zhou, Yuan4 ; Chou, Kun-Hsien5; Chen, I-Yun5; Jiang, Tianzi1,6,7; Lin, Ching-Po5
|
| 刊名 | NEUROIMAGE
 |
| 出版日期 | 2012-01-16 |
| 卷号 | 59期号:2页码:1085-1093 |
| 关键词 | Anatomical connectivity Diffusion tensor imaging Graph theory Small-world Schizophrenia |
| 英文摘要 | Schizophrenia is characterized by lowered efficiency in distributed information processing, as indicated by research that identified a disrupted small-world functional network. However, whether the dysconnection manifested by the disrupted small-world functional network is reflected in underlying anatomical disruption in schizophrenia remains unresolved. This study examined the topological properties of human brain anatomical networks derived from diffusion tensor imaging in patients with schizophrenia and in healthy controls. We constructed the weighted brain anatomical network for each of 79 schizophrenia patients and for 96 age and gender matched healthy subjects using diffusion tensor tractography and calculated the topological properties of the networks using a graph theoretical method. The topological properties of the patients' anatomical networks were altered, in that global efficiency decreased but local efficiency remained unchanged. The deleterious effects of schizophrenia on network performance appear to be localized as reduced regional efficiency in hubs such as the frontal associative cortices, the paralimbic/limbic regions and a subcortical structure (the left putamen). Additionally, scores on the Positive and Negative Symptom Scale correlated negatively with efficient network properties in schizophrenia. These findings suggest that complex brain network analysis may potentially be used to detect an imaging biomarker for schizophrenia. (C) 2011 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | WHITE-MATTER INTEGRITY ; GRAPH-THEORETICAL ANALYSIS ; COMPLEX BRAIN NETWORKS ; LONGITUDINAL FASCICULUS ; FUNCTIONAL CONNECTIVITY ; ONSET SCHIZOPHRENIA ; DIFFUSION ; TRACTOGRAPHY ; MRI ; ABNORMALITIES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000298210600028 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3167]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 2.Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan 3.Natl Yang Ming Univ, Collage Med, Dept Psychiat, Taipei 112, Taiwan 4.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 5.Natl Yang Ming Univ, Inst Neurosci, Brain Connect Lab, Taipei 112, Taiwan 6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China 7.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia |
| 推荐引用方式 GB/T 7714 | Wang, Qifeng,Su, Tung-Ping,Zhou, Yuan,et al. Anatomical insights into disrupted small-world networks in schizophrenia[J]. NEUROIMAGE,2012,59(2):1085-1093. |
| APA | Wang, Qifeng.,Su, Tung-Ping.,Zhou, Yuan.,Chou, Kun-Hsien.,Chen, I-Yun.,...&Lin, Ching-Po.(2012).Anatomical insights into disrupted small-world networks in schizophrenia.NEUROIMAGE,59(2),1085-1093. |
| MLA | Wang, Qifeng,et al."Anatomical insights into disrupted small-world networks in schizophrenia".NEUROIMAGE 59.2(2012):1085-1093. |
入库方式： OAI收割
来源：自动化研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。