Altered spontaneous activity in Alzheimer's disease and mild cognitive impairment revealed by Regional Homogeneity
文献类型：期刊论文
| 作者 | Zhang, Zengqiang1; Liu, Yong2 ; Jiang, Tianzi2,3,4; Zhou, Bo1; An, Ningyu5; Dai, Haitao1; Wang, Pan1; Niu, Yixuan1; Wang, Luning1; Zhang, Xi1
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| 刊名 | NEUROIMAGE
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| 出版日期 | 2012-01-16 |
| 卷号 | 59期号:2页码:1429-1440 |
| 关键词 | Regional Homogeneity Resting state Functional magnetic resonance imaging Alzheimer's disease Mild cognitive impairment |
| 英文摘要 | Alzheimer's disease (AD), the most prevalent cause of dementia in the elderly, is characterized by progressive cognitive and intellectual deficits. Most patients with mild cognitive impairment (MCI) are thought to be in a very early stage of AD. Resting-state functional magnetic resonance imaging reflects spontaneous brain activities and/or the endogenous/background neurophysiological process of the human brain. Regional Homogeneity (ReHo) can provide a fast method for mapping regional activity across the whole brain. Little has been previously published about where or how spontaneous activity differs between MCI and AD, although many previous fMRI studies have shown that the activity pattern is altered in MCI/AD. In the present study, we first used the ReHo method to explore differences in regional spontaneous activities throughout the whole brain between normal controls (NC) and people with MCI and with AD. A one-way ANOVA was performed to determine the regions in which the ReHo differs between the three groups, and then a post hoc analysis was performed to evaluate differences in the pattern among the three groups. Finally a correlation analysis was clone between the ReHo index of these regions and clinical variables in order to evaluate the relationship between ReHo and cognitive measures in the AD and MCI groups. An exploratory classification analysis also demonstrated that ReHo measures were able to correctly separate subjects in 71.4% of the cases. Altered brain spontaneous activations were found in the medial prefrontal cortex, the bilateral posterior cingulate gyrus/precuneus and the left inferior parietal lobule (IPL) in both MCI and AD. In MCI, the ReHo index in the left IPL was higher than that of the NC, which could indicate the presence of a compensatory mechanism in MCI. More obviously, the correlation analysis indicated that the lower the memory and other cognitive abilities, the lower the ReHo in patients with MCI and AD. Combining our findings with the results in earlier studies, we propose that the spontaneous activity pattern in the resting state could potentially be used as a clinical marker for MCI/AD. (C) 2011 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | DEFAULT-MODE NETWORK ; STATE FUNCTIONAL MRI ; BRAIN ACTIVITY ; EPISODIC MEMORY ; SPONTANEOUS FLUCTUATIONS ; CORTICAL THICKNESS ; CINGULATE CORTEX ; CEREBRAL-CORTEX ; FMRI ; DEMENTIA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000298210600062 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3168]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Chinese Peoples Liberat Army Gen Hosp, Dept Neurol, Inst Gerontol & Geriatr, Beijing 100853, Peoples R China 2.Chinese Acad Sci, Natl Lab Patient Recognit, Inst Automat, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China 3.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab Neuroinformat, Minist Educ, Chengdu 610054, Peoples R China 4.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia 5.Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing 100853, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zengqiang,Liu, Yong,Jiang, Tianzi,et al. Altered spontaneous activity in Alzheimer's disease and mild cognitive impairment revealed by Regional Homogeneity[J]. NEUROIMAGE,2012,59(2):1429-1440. |
| APA | Zhang, Zengqiang.,Liu, Yong.,Jiang, Tianzi.,Zhou, Bo.,An, Ningyu.,...&Zhang, Xi.(2012).Altered spontaneous activity in Alzheimer's disease and mild cognitive impairment revealed by Regional Homogeneity.NEUROIMAGE,59(2),1429-1440. |
| MLA | Zhang, Zengqiang,et al."Altered spontaneous activity in Alzheimer's disease and mild cognitive impairment revealed by Regional Homogeneity".NEUROIMAGE 59.2(2012):1429-1440. |
入库方式： OAI收割
来源：自动化研究所
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