Aberrant Functional Organization within and between Resting-State Networks in AD
文献类型：期刊论文
| 作者 | Song, Jinyu1; Qin, Wen1; Liu, Yong2 ; Duan, Yunyun4; Liu, Jieqiong3; He, Xiaoxi1; Li, Kuncheng4; Zhang, Xinqing3; Jiang, Tianzi2; Yu, Chunshui1
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| 刊名 | PLOS ONE
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| 出版日期 | 2013-05-07 |
| 卷号 | 8期号:5 |
| 英文摘要 | Altered functional characteristics have been reported in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD); nonetheless, comprehensive analyses of the resting-state networks (RSNs) are rare. This study combined multiple imaging modalities to investigate the functional and structural changes within each RSN and between RSNs in aMCI/AD patients. Eight RSNs were identified from functional MRI data from 35 AD, 18 aMCI and 21 normal control subjects using independent component analysis. We compared functional connectivity (FC) within each RSN and found decreased FC in the several cognitive-related RSNs in AD, including the bilateral precuneus of the precuneus network, the posterior cingulate cortex and left precuneus of the posterior default mode network (DMN), and the left superior parietal lobule of the left frontoparietal network (LFP). We further compared the grey matter volumes and amplitudes of low-frequency fluctuations of these regions and found decreases in these measures in AD. Importantly, we found decreased inter-network connectivity between the visual network and the LFP and between the anterior and posterior DMNs in AD. All indices in aMCI patients were numerically between those of controls and AD patients. These results suggest that the brain networks supporting complex cognitive processes are specifically and progressively impaired over the course of AD, and the FC impairments are present not only within networks but also between networks. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | MILD COGNITIVE IMPAIRMENT ; DEFAULT-MODE NETWORK ; DISTINCT BRAIN NETWORKS ; ALZHEIMERS-DISEASE ; CONNECTIVITY NETWORKS ; POSTERIOR CINGULATE ; EXECUTIVE FUNCTION ; CORTICAL NETWORKS ; VISUAL-ATTENTION ; MRI DATA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000319654700181 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3176]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 3.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China 4.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Jinyu,Qin, Wen,Liu, Yong,et al. Aberrant Functional Organization within and between Resting-State Networks in AD[J]. PLOS ONE,2013,8(5). |
| APA | Song, Jinyu.,Qin, Wen.,Liu, Yong.,Duan, Yunyun.,Liu, Jieqiong.,...&Yu, Chunshui.(2013).Aberrant Functional Organization within and between Resting-State Networks in AD.PLOS ONE,8(5). |
| MLA | Song, Jinyu,et al."Aberrant Functional Organization within and between Resting-State Networks in AD".PLOS ONE 8.5(2013). |
入库方式： OAI收割
来源：自动化研究所
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