Altered Spontaneous Activity in Anisometropic Amblyopia Subjects: Revealed by Resting-State fMRI
文献类型：期刊论文
| 作者 | Lin, Xiaoming1; Ding, Kun1 ; Liu, Yong2; Yan, Xiaohe1; Song, Shaojie1; Jiang, Tianzi2,3,4
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| 刊名 | PLOS ONE
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| 出版日期 | 2012-08-24 |
| 卷号 | 7期号:8 |
| 英文摘要 | Amblyopia, also known as lazy eye, usually occurs during early childhood and results in poor or blurred vision. Recent neuroimaging studies have found cortical structural/functional abnormalities in amblyopia. However, until now, it was still not known whether the spontaneous activity of the brain changes in amblyopia subjects. In the present study, regional homogeneity (ReHo), a measure of the homogeneity of functional magnetic resonance imaging signals, was used for the first time to investigate changes in resting-state local spontaneous brain activity in individuals with anisometropic amblyopia. Compared with age-and gender-matched subjects with normal vision, the anisometropic amblyopia subjects showed decreased ReHo of spontaneous brain activity in the right precuneus, the left medial prefrontal cortex, the left inferior frontal gyrus, and the left cerebellum, and increased ReHo of spontaneous brain activity was found in the bilateral conjunction area of the postcentral and precentral gyri, the left paracentral lobule, the left superior temporal gyrus, the left fusiform gyrus, the conjunction area of the right insula, putamen and the right middle occipital gyrus. The observed decreases in ReHo may reflect decreased visuo-motor processing ability, and the increases in ReHo in the somatosensory cortices, the motor areas and the auditory area may indicate compensatory plasticity in amblyopia. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | TRANSCRANIAL MAGNETIC STIMULATION ; DIFFUSION TENSOR TRACTOGRAPHY ; POSITRON-EMISSION-TOMOGRAPHY ; REGIONAL HOMOGENEITY CHANGES ; LATERAL GENICULATE-NUCLEUS ; VERGENCE EYE-MOVEMENTS ; ABNORMAL VISUAL-CORTEX ; FUNCTIONAL CONNECTIVITY ; EARLY BLINDNESS ; BRAIN ACTIVITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000308225500045 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3180]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Sun Yat Sen Univ, State Key Lab Ophthalmol, Zhongshan Ophthalm Ctr, Guangzhou 510275, Guangdong, Peoples R China 2.Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing, Peoples R China 3.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China 4.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia |
| 推荐引用方式 GB/T 7714 | Lin, Xiaoming,Ding, Kun,Liu, Yong,et al. Altered Spontaneous Activity in Anisometropic Amblyopia Subjects: Revealed by Resting-State fMRI[J]. PLOS ONE,2012,7(8). |
| APA | Lin, Xiaoming,Ding, Kun,Liu, Yong,Yan, Xiaohe,Song, Shaojie,&Jiang, Tianzi.(2012).Altered Spontaneous Activity in Anisometropic Amblyopia Subjects: Revealed by Resting-State fMRI.PLOS ONE,7(8). |
| MLA | Lin, Xiaoming,et al."Altered Spontaneous Activity in Anisometropic Amblyopia Subjects: Revealed by Resting-State fMRI".PLOS ONE 7.8(2012). |
入库方式： OAI收割
来源：自动化研究所
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