Disrupted Small-World Brain Networks in Moderate Alzheimer's Disease: A Resting-State fMRI Study
文献类型：期刊论文
| 作者 | Zhao, Xiaohu1; Liu, Yong2 ; Wang, Xiangbin1; Liu, Bing2; Xi, Qian1; Guo, Qihao3; Jiang, Hong1; Jiang, Tianzi2,4,5; Wang, Peijun1
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| 刊名 | PLOS ONE
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| 出版日期 | 2012-03-23 |
| 卷号 | 7期号:3 |
| 英文摘要 | The small-world organization has been hypothesized to reflect a balance between local processing and global integration in the human brain. Previous multimodal imaging studies have consistently demonstrated that the topological architecture of the brain network is disrupted in Alzheimer's disease (AD). However, these studies have reported inconsistent results regarding the topological properties of brain alterations in AD. One potential explanation for these inconsistent results lies with the diverse homogeneity and distinct progressive stages of the AD involved in these studies, which are thought to be critical factors that might affect the results. We investigated the topological properties of brain functional networks derived from resting functional magnetic resonance imaging (fMRI) of carefully selected moderate AD patients and normal controls (NCs). Our results showed that the topological properties were found to be disrupted in AD patients, which showing increased local efficiency but decreased global efficiency. We found that the altered brain regions are mainly located in the default mode network, the temporal lobe and certain subcortical regions that are closely associated with the neuropathological changes in AD. Of note, our exploratory study revealed that the ApoE genotype modulates brain network properties, especially in AD patients. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | MILD COGNITIVE IMPAIRMENT ; GRAPH-THEORETICAL ANALYSIS ; NORMAL ELDERLY SUBJECTS ; APOE EPSILON-4 ALLELE ; FUNCTIONAL CONNECTIVITY ; CEREBRAL-CORTEX ; DEFAULT-MODE ; DISCONNECTION SYNDROME ; REGIONAL HOMOGENEITY ; CLINICAL-FEATURES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000304046900016 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3184]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Tongji Univ, TongJi Hosp Shanghai, Dept Imaging, Shanghai, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing, Peoples R China 3.Fudan Univ, Shanghai Med Coll, Huashan Hosp,State Key Lab Med Neurobiol, Dept Neurol,Inst Neurol, Shanghai 200433, Peoples R China 4.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China 5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia |
| 推荐引用方式 GB/T 7714 | Zhao, Xiaohu,Liu, Yong,Wang, Xiangbin,et al. Disrupted Small-World Brain Networks in Moderate Alzheimer's Disease: A Resting-State fMRI Study[J]. PLOS ONE,2012,7(3). |
| APA | Zhao, Xiaohu.,Liu, Yong.,Wang, Xiangbin.,Liu, Bing.,Xi, Qian.,...&Wang, Peijun.(2012).Disrupted Small-World Brain Networks in Moderate Alzheimer's Disease: A Resting-State fMRI Study.PLOS ONE,7(3). |
| MLA | Zhao, Xiaohu,et al."Disrupted Small-World Brain Networks in Moderate Alzheimer's Disease: A Resting-State fMRI Study".PLOS ONE 7.3(2012). |
入库方式： OAI收割
来源：自动化研究所
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