The Neuronal Correlates of Digits Backward Are Revealed by Voxel-Based Morphometry and Resting-State Functional Connectivity Analyses
文献类型：期刊论文
| 作者 | Li, Rui1 ; Qin, Wen1; Zhang, Yunting1; Jiang, Tianzi2; Yu, Chunshui1
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| 刊名 | PLOS ONE
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| 出版日期 | 2012-02-16 |
| 卷号 | 7期号:2 |
| 英文摘要 | Digits backward (DB) is a widely used neuropsychological measure that is believed to be a simple and effective index of the capacity of the verbal working memory. However, its neural correlates remain elusive. The aim of this study is to investigate the neural correlates of DB in 299 healthy young adults by combining voxel-based morphometry (VBM) and resting-state functional connectivity (rsFC) analyses. The VBM analysis showed positive correlations between the DB scores and the gray matter volumes in the right anterior superior temporal gyrus (STG), the right posterior STG, the left inferior frontal gyrus and the left Rolandic operculum, which are four critical areas in the auditory phonological loop of the verbal working memory. Voxel-based correlation analysis was then performed between the positive rsFCs of these four clusters and the DB scores. We found that the DB scores were positively correlated with the rsFCs within the salience network (SN), that is, between the right anterior STG, the dorsal anterior cingulate cortex and the right fronto-insular cortex. We also found that the DB scores were negatively correlated with the rsFC within an anti-correlation network of the SN, between the right posterior STG and the left posterior insula. Our findings suggest that DB performance is related to the structural and functional organizations of the brain areas that are involved in the auditory phonological loop and the SN. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | ANTERIOR CINGULATE CORTEX ; VERBAL WORKING-MEMORY ; SUPERIOR TEMPORAL GYRUS ; DEFAULT-MODE NETWORKS ; MEDIAL FRONTAL-CORTEX ; HUMAN AUDITORY-CORTEX ; EVENT-RELATED FMRI ; SHORT-TERM-MEMORY ; ALZHEIMERS-DISEASE ; BRAIN ACTIVATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000302796200108 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/3185]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin, Peoples R China 2.Chinese Acad Sci, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Rui,Qin, Wen,Zhang, Yunting,et al. The Neuronal Correlates of Digits Backward Are Revealed by Voxel-Based Morphometry and Resting-State Functional Connectivity Analyses[J]. PLOS ONE,2012,7(2). |
| APA | Li, Rui,Qin, Wen,Zhang, Yunting,Jiang, Tianzi,&Yu, Chunshui.(2012).The Neuronal Correlates of Digits Backward Are Revealed by Voxel-Based Morphometry and Resting-State Functional Connectivity Analyses.PLOS ONE,7(2). |
| MLA | Li, Rui,et al."The Neuronal Correlates of Digits Backward Are Revealed by Voxel-Based Morphometry and Resting-State Functional Connectivity Analyses".PLOS ONE 7.2(2012). |
入库方式： OAI收割
来源：自动化研究所
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