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Altered Functional Connectivity of the Marginal Division in Alzheimer's Disease

文献类型：期刊论文

作者Zhang, Zengqiang1,4; Liu, Yong2,3; Zhou, Bo1; Zheng, Jinlong5; Yao, Hongxiang6; An, Ningyu6; Wang, Pan1; Guo, Yan'e1; Dai, Haitao4; Wang, Luning1
刊名CURRENT ALZHEIMER RESEARCH
出版日期2014-02-01
卷号11期号:2页码:145-155
关键词Alzheimer's disease functional connectivity marginal division mild cognitive impairment resting-state fMRI
英文摘要The marginal division (MrD) is a neostriatum subregion that links the limbic system and basal nucleus of Meynert; it is an important subcortical center that is involved in learning and memory. Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia in the elderly. AD clinically manifests as gradually progressive cognitive decline with behavioral disorders. Prior to full dementia, AD patients typically experience a transient state, i.e., mild cognitive impairment (MCI). Amnestic MCI individuals, but not all MCI individuals, frequently convert to AD dementia. To specify whether and how the functional relationships between the MrD and other brain regions change during AD, functional connectivity was assessed using resting-state functional MRI data and associated neuropsychological tests in AD and MCI patients (amnestic-type). Compared with normal controls, a different decreased functional connectivity pattern was observed between the MrD and caudate, the amygdala/parahippocampal region, the inferior frontal gyrus, the superior temporal gyrus, and the cerebellum for AD/MCI patients. Moreover, the functional connectivity between the MrD and the identified regions was significantly correlated with the neuropsychological scores among the MCI and AD subjects. Our results suggest that the MrD functional network is disrupted during AD.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Clinical Neurology ; Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]MILD COGNITIVE IMPAIRMENT ; RESTING-STATE FMRI ; LONG-TERM POTENTIATION ; POSTERIOR CINGULATE CORTEX ; HUMAN AMYGDALA ; DISCONNECTION SYNDROME ; REGIONAL HOMOGENEITY ; EMOTIONAL FACES ; CAUDATE-NUCLEUS ; LIMBIC SYSTEM
收录类别SCI
语种英语
WOS记录号WOS:000333195900006
源URL[http://ir.ia.ac.cn/handle/173211/3196]  
专题自动化研究所_脑网络组研究中心
作者单位1.Chinese Peoples Liberat Army Gen Hosp, Inst Gerontol & Geriatr, Dept Neurol, Beijing 100853, Peoples R China
2.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
4.Chinese Peoples Liberat Army Gen Hosp, Hainan Branch, Sanya 572014, Peoples R China
5.Xuzhou Med Coll, Dept Neurol, Huaian Hosp 2, Huaian 223002, Peoples R China
6.Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing 100853, Peoples R China
7.Southern Med Univ, ZhuJiang Hosp, Dept Pediat, Guangzhou 510280, Guangdong, Peoples R China
8.Univ Elect Sci & Technol China, Key Lab NeuroInformat, Sch Life Sci & Technol, Minist Educ, Chengdu 610054, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Zengqiang,Liu, Yong,Zhou, Bo,et al. Altered Functional Connectivity of the Marginal Division in Alzheimer's Disease[J]. CURRENT ALZHEIMER RESEARCH,2014,11(2):145-155.
APA Zhang, Zengqiang.,Liu, Yong.,Zhou, Bo.,Zheng, Jinlong.,Yao, Hongxiang.,...&Jiang, Tianzi.(2014).Altered Functional Connectivity of the Marginal Division in Alzheimer's Disease.CURRENT ALZHEIMER RESEARCH,11(2),145-155.
MLA Zhang, Zengqiang,et al."Altered Functional Connectivity of the Marginal Division in Alzheimer's Disease".CURRENT ALZHEIMER RESEARCH 11.2(2014):145-155.

入库方式： OAI收割

来源：自动化研究所

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